Alkalized MXene/laser-induced graphene-based integrated three-electrode devices for micro-droplet detection of albendazole

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-04-10 DOI:10.1016/j.aca.2025.344051

Xin Zhou , Mei Liu , Bin Yang , Can Wu , Kangbing Wu , Shiran Sun

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Abstract

Background

Albendazole is a commonly-used antiparasitic drug that has been extensively applied in animal husbandry and aquaculture to prevent and treat various parasitic infections. However, the potential residues of albendazole in animal-derived foods and the aquatic environment can pose risks to human health and ecological balance. Hence, the development of a highly sensitive and rapid analytical method for albendazole is of utmost importance to safeguard food safety and preserve the ecological environment. MXene nanosheets (Ti₃C₂T_x) are emerging as promising precursors for the design of such detection systems. (86)

Results

In this work, MXene nanosheets (Ti₃C₂T_x) were alkalized in NaOH solution to form alkalized Ti₃C₂T_x (Al-MXene). The treatment caused structural changes such as expanded interlayer spacing, reduced particle size, enhanced Zeta potential, and the formation of amorphous TiO₂ on the surface. These modifications gave Al-MXene larger electrochemical active specific area and stronger physical adsorption capacity for albendazole compared to the original MXene nanosheets. When Al-MXene was decorated on the surface of laser-induced graphene (LIG), albendazole was efficiently oxidized due to the unique surface activity of Al-MXene and the abundant three-dimensional porous structure of LIG. An integrated three-electrode device based on the Al-MXene/LIG structure was fabricated for the electrochemical detection of albendazole in micro-droplets for milk sample. The device showed a linear detection range from 10 nM to 1 μM, a sensitivity of 411 μA μmoL⁻¹ cm⁻², and a detection limit of 7.5 nM (143)

Significance

The development of the integrated three-electrode device based on Al-MXene/LIG provides a highly sensitive and efficient method for detecting albendazole in milk samples. Moreover, it can also offer guidance for fabricating more innovative electrochemical sensors for the rapid screening of veterinary drug residues. This contribution is of great significance in ensuring food safety and protecting public health. (57)

Abstract Image

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基于碱化 MXene/激光诱导石墨烯的集成三电极装置，用于阿苯达唑的微滴检测

背景苯达唑是一种常用的抗寄生虫药物，在畜牧业和水产养殖中广泛应用于预防和治疗各种寄生虫感染。然而，阿苯达唑在动物性食品和水生环境中的潜在残留可能对人类健康和生态平衡构成威胁。因此，开发一种高灵敏度、快速的阿苯达唑分析方法对保障食品安全和保护生态环境具有重要意义。MXene纳米片（Ti3C2Tx）正在成为设计这种检测系统的有前途的前体。（86）结果将MXene纳米片（Ti3C2Tx）在NaOH溶液中碱化，得到碱化Ti3C2Tx （Al-MXene）。该处理引起了结构变化，如层间距扩大，颗粒尺寸减小，Zeta电位增强，表面形成无定形TiO2。与原始MXene纳米片相比，这些修饰使Al-MXene的电化学活性比面积更大，对阿苯达唑的物理吸附能力更强。当Al-MXene修饰在激光诱导石墨烯（LIG）表面时，由于Al-MXene独特的表面活性和LIG丰富的三维多孔结构，阿苯达唑被有效氧化。制作了一种基于Al-MXene/LIG结构的集成三电极装置，用于牛奶样品微液滴中阿苯达唑的电化学检测。该器件的线性检测范围为10 ~ 1 μM，灵敏度为411 μA μmoL-1 cm-2，检出限为7.5 nM。（143）意义基于Al-MXene/LIG的集成三电极装置的开发为检测牛奶样品中的阿苯达唑提供了一种高灵敏度和高效率的方法。此外，还可以为制造更多创新的用于兽药残留快速筛选的电化学传感器提供指导。这对确保食品安全和保护公众健康具有重要意义。（57)

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.