[18F]Radiolabeling Fluorination of Monofluoroalkyl Triflates for the Synthesis of [18]Difluoromethylated Alkanes

Abstract

An efficient method for the synthesis of [18F]-difluoromethylated alkanes has been developed by combining [18F]radiofluoride with monofluoroalkyl triflates. This method uses [18F]KF/K2.2.2. as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.