Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants

IF 15.8 1区 生物学 Q1 PLANT SCIENCES
Michael J. Prigge, Nicholas Morffy, Amber de Neve, Whitnie Szutu, María Jazmín Abraham-Juárez, Trisha McAllister, Heather Jones, Kjel Johnson, Nicole Do, Meirav Lavy, Sarah Hake, Lucia C. Strader, Mark Estelle, Annis E. Richardson
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Abstract

The plant hormone auxin regulates a wide variety of transcriptional responses depending on the cell type, environment and species. How this diversity is achieved may be related to the specific complement of auxin-signalling components in each cell. The levels of activators (class-A AUXIN RESPONSE FACTORS) and repressors (class-B ARFs) are particularly important. Tight regulation of ARF protein levels is probably key in determining this balance. Through comparative analysis of novel, dominant mutants in maize and the moss Physcomitrium patens, we have discovered a ~500-million-year-old mechanism of class-B ARF protein-level regulation mediated by proteasome degradation, important in determining cell fate decisions across land plants. Thus, our results add a key piece to the puzzle of how auxin regulates plant development.

Abstract Image

比较突变体分析揭示了陆生植物ARF调控的新机制
植物激素生长素根据细胞类型、环境和物种调节多种转录反应。如何实现这种多样性可能与每个细胞中生长素信号成分的特定补体有关。激活因子(a类生长素反应因子)和抑制因子(b类arf)的水平尤为重要。严格调节ARF蛋白水平可能是决定这种平衡的关键。通过对玉米和苔藓中新型显性突变体的比较分析,我们发现了一种约5亿年历史的由蛋白酶体降解介导的b类ARF蛋白水平调控机制,该机制在决定陆地植物细胞命运决策中具有重要意义。因此,我们的研究结果为生长素如何调节植物发育这一谜题增添了关键的一块。
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来源期刊
Nature Plants
Nature Plants PLANT SCIENCES-
CiteScore
25.30
自引率
2.20%
发文量
196
期刊介绍: Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.
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