Substituted Pyridinium N-Chloramines: Chemical Synthesis and Antibacterial Application

Abstract

In this work, synthesis on pyridinium N-chloramines based on substituted pyridine was explored and three series of N-chloramines were prepared. Preliminary antibacterial tests showed that electron-donating (ED) group substituted pyridinium N-chloramines (e.g., 17–19) exerted the most efficacious antibacterial activity in contrast with electron-withdrawing (EW) group or alkyl group substituted counterparts. In addition, para-substitued pyridinium N-chloramines (11, 17, and 19) with symmetric cationic moiety comparatively demonstrated even superior biocidal efficacy. Our study provided highly efficacious N-chloramine biocides, offering valuable references to design new biocides with even more powerful antibacterial potency.