Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-10 DOI:10.1002/advs.202570098

Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo

引用次数: 0

Abstract

Crizotinib Hepatotoxicity

In article number 2414923, Peihua Luo, Hao Yan, Xiangliang Huang, and co-workers report the mechanism of crizotinib hepatotoxicity, wherein crizotinib disturbs normal lipid metabolism through accumulation of squalene epoxidase (SQLE). The liver damage caused by crizotinib is similar to persistent sunshine exposure, which causes desertification changes in the “liver land,” whereas rainfall (representing metformin and terbinafine) can prevent such alterations.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.