{"title":"Mesenchymal Stem Cell Treatment for Peripheral Nerve Injuries","authors":"Yue Wu, Ruijie Lu, Hongtao Yin, Deqing Peng, Ruolang Pan, Liangzhong Lv","doi":"10.1002/jcp.70031","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Peripheral nerve injuries (PNI) affect hundreds of thousands of patients annually, often leading to life-altering consequences such as significant impairments in motor function and sensory perception. In recent years, a growing body of evidence indicates that mesenchymal stem cell (MSC) treatment could complement traditional treatment and improve therapeutic outcomes for these injuries. This paper reviews emerging insights into the potential benefits of MSC treatment for PNI and summarizes selected examples of the interactions between MSCs, peripheral nerves, and their microenvironment, which have advanced our understanding of the pathophysiology of MSC-based therapy. We believe that this rapidly moving field holds great promise for future advancements, guiding the rational design of safe and effective treatments for patients with PNI.</p></div>","PeriodicalId":15220,"journal":{"name":"Journal of Cellular Physiology","volume":"240 4","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cellular Physiology","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jcp.70031","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Peripheral nerve injuries (PNI) affect hundreds of thousands of patients annually, often leading to life-altering consequences such as significant impairments in motor function and sensory perception. In recent years, a growing body of evidence indicates that mesenchymal stem cell (MSC) treatment could complement traditional treatment and improve therapeutic outcomes for these injuries. This paper reviews emerging insights into the potential benefits of MSC treatment for PNI and summarizes selected examples of the interactions between MSCs, peripheral nerves, and their microenvironment, which have advanced our understanding of the pathophysiology of MSC-based therapy. We believe that this rapidly moving field holds great promise for future advancements, guiding the rational design of safe and effective treatments for patients with PNI.
期刊介绍：
The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics, proteomics, bioinformatics and systems biology. In particular, the Journal encourages submission of high-interest papers investigating the genetic and epigenetic regulation of proliferation and phenotype as well as cell fate and lineage commitment by growth factors, cytokines and their cognate receptors and signal transduction pathways that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules in addition to the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, cell fate, lineage commitment, differentiation, development and dynamic parameters of cell motility are encouraged. Finally, the investigation of stem cells and changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.
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