Mesenchymal stem cells and their exosomes: a novel approach to skin regeneration via signaling pathways activation

IF 2.9 4区生物学 Q3 CELL BIOLOGY

Journal of Molecular Histology Pub Date : 2025-04-10 DOI:10.1007/s10735-025-10394-7

Maryam Kananivand, Fatemeh Nouri, Mohammad Hasan Yousefi, Ali Pajouhi, Hakimeah Ghorbani, Hamed Afkhami, Zahra Sadat Razavi

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引用次数: 0

Abstract

Accelerating wound healing is a crucial objective in surgical and regenerative medicine. The wound healing process involves three key stages: inflammation, cell proliferation, and tissue repair. Mesenchymal stem cells (MSCs) have demonstrated significant therapeutic potential in promoting tissue regeneration, particularly by enhancing epidermal cell migration and proliferation. However, the precise molecular mechanisms underlying MSC-mediated wound healing remain unclear. This review highlights the pivotal role of MSCs and their exosomes in wound repair, with a specific focus on critical signaling pathways, including PI3K/Akt, WNT/β-catenin, Notch, and MAPK. These pathways regulate essential cellular processes such as proliferation, differentiation, and angiogenesis. Moreover, in vitro and in vivo studies reveal that MSCs accelerate wound closure, enhance collagen deposition, and modulate immune responses, contributing to improved tissue regeneration. Understanding these mechanisms provides valuable insights into MSC-based therapeutic strategies for enhancing wound healing.

Graphical abstract

Effects of mesenchymal stem cell and its derived-exosome treatment on skin regeneration and tissue repair via activation of different signaling pathways

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间充质干细胞及其外泌体：通过信号通路激活皮肤再生的新途径

加速伤口愈合是外科和再生医学的一个重要目标。伤口愈合过程包括三个关键阶段：炎症、细胞增殖和组织修复。间充质干细胞（MSCs）在促进组织再生方面具有显著的治疗潜力，特别是通过增强表皮细胞的迁移和增殖。然而，msc介导的伤口愈合的确切分子机制尚不清楚。这篇综述强调了MSCs及其外泌体在伤口修复中的关键作用，特别关注关键信号通路，包括PI3K/Akt， WNT/β-catenin， Notch和MAPK。这些通路调节基本的细胞过程，如增殖、分化和血管生成。此外，体外和体内研究表明，MSCs加速伤口愈合，增强胶原沉积，调节免疫反应，有助于改善组织再生。了解这些机制为基于骨髓间质干细胞的治疗策略提供了有价值的见解，以促进伤口愈合。间充质干细胞及其衍生外泌体通过激活不同信号通路对皮肤再生和组织修复的影响

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.