Recent advancements in the multifaceted biomedical efficacy of triazole based metal complexes

Abstract

In the last two decades, complexes of N-heterocycles especially of 1,2,3- and 1,2,4-triazoles have attracted the researcher's attention most due to their easier synthetic access and tremendous potential in several fields including catalysis, agricultural science, materials science, medicinal chemistry, photochemistry, etc. As triazoles played an important role in the modern era drug development but the discovery of their metal complexes with superior efficacy towards various diseases changed the course of medication development. Triazoles and their metal complexes were found to possess unique physicochemical properties important for rational drug designing. The high stability, easy synthesis, and ability to show various interactions with biological targets prompted the medicinal chemists to develop new triazole based metal complexes with better therapeutic efficacy and novel mode of action. In this review, we have summarized multifaceted biomedical efficacy of triazole based metal complexes in terms of their antimicrobial, antidiabetic, anticancer, antimalarial, antioxidant, anti-HIV, etc., activities. This comprehensive review will provide important insights into triazole based metal complexes and their most intriguing biological potential thereby stimulating future research for the development of lead molecules.