Imaging probes for the detection of brain microenvironment

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-02 DOI:10.1016/j.colsurfb.2025.114677

Shiming Zhang , Tianyu Wang , Tianzi Gao , Jun Liao , Yang Wang , Meng Xu , Changyu Lu , Jianfeng Liang , Zhengren Xu , Jianfei Sun , Qian Xie , Zhiqiang Lin , Hongbin Han

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Abstract

The brain microenvironment (BME) is a highly dynamic system that plays a critical role in neural excitation, signal transmission, development, aging, and neurological disorders. BME consists of three key components: neural cells, extracellular spaces, and physical fields, which provide structures and physicochemical properties to synergistically and antagonistically regulate cell behaviors and functions such as nutrient transport, waste metabolism and intercellular communication. Consequently, monitoring the BME is vital to acquire a better understanding of the maintenance of neural homeostasis and the mechanisms underlying neurological diseases. In recent years, researchers have developed a range of imaging probes designed to detect changes in the microenvironment, enabling precise measurements of structural and biophysical parameters in the brain. This advancement aids in the development of improved diagnostic and therapeutic strategies for brain disorders and in the exploration of cutting-edge mechanisms in neuroscience. This review summarizes and highlights recent advances in the probes for sensing and imaging BME. Also, we discuss the design principles, types, applications, challenges, and future directions of probes.

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用于检测大脑微环境的成像探针

脑微环境（brain microenvironment， BME）是一个高度动态的系统，在神经兴奋、信号传递、发育、衰老和神经系统疾病中起着至关重要的作用。BME由神经细胞、细胞外空间和物理场三个关键部分组成，它们提供结构和物理化学性质，协同和拮抗调节营养物质运输、废物代谢和细胞间通讯等细胞行为和功能。因此，监测BME对于更好地了解神经稳态的维持和神经系统疾病的机制至关重要。近年来，研究人员开发了一系列成像探针，用于检测微环境的变化，从而能够精确测量大脑的结构和生物物理参数。这一进步有助于改善脑部疾病的诊断和治疗策略的发展，并有助于探索神经科学的前沿机制。本文综述并重点介绍了用于BME传感和成像的探针的最新进展。此外，我们还讨论了探针的设计原理、类型、应用、挑战和未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.