Early detection of unusual cryoglobulinemia from automated cell counts and blood films

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-09 DOI:10.1016/j.cca.2025.120290

Bob Smit , Ilse JE Kouijzer , Wilbert AG van der Meijden , Ayden Kleij , Corrie M de Kat Angelino , Charissa Wijnands , Laura Belt , Annette Vendel , Raphaël Duivenvoorden , Joannes FM Jacobs

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引用次数: 0

Abstract

Cryoglobulins are circulating immunoglobulins characterized by reversible cold-induced precipitation. The process of serum cryoprecipitation, performed at 4 °C, takes three to seven days, which leads to delays in obtaining cryoglobulinemia lab-results. Here, we report two cases of cryoglobulinemia, each with distinct cryoglobulin-induced features that were identifiable through automated hemocytometry and blood smear analysis. The blood smear showed neutrophilic inclusions and amorphous extra-cellular material, and the automated hematology analyzer displayed abnormal scatterplots. All these unique features positively correlated with the duration the blood sample was kept at room temperature prior to analysis. These hemocytometric abnormalities may serve as early indicators for the diagnosis of cryoglobulinemia, potentially aiding the detection of this condition.

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通过自动细胞计数和血膜早期发现异常的冷球蛋白血症

低温球蛋白是一种循环免疫球蛋白，其特征是可逆的冷诱导沉淀。在4°C下进行血清低温沉淀的过程需要3至7天，这导致获得低温球蛋白血症实验室结果的延迟。在这里，我们报告了两例低温球蛋白血症，每个病例都有不同的低温球蛋白诱导特征，通过自动血细胞计数和血液涂片分析可识别。血液涂片显示中性粒细胞包涵体和无定形细胞外物质，自动血液学分析仪显示异常散点图。所有这些独特的特征都与血液样本在分析前在室温下保存的时间呈正相关。这些血细胞计数异常可以作为诊断冷球蛋白血症的早期指标，可能有助于发现这种情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.