{"title":"Recent progress of carbon-based quantum dots and nanotubes for cancer targeting and drug delivery applications","authors":"Sudipta Mondal , Subhadeep Das , Binayok Sharma , Rajashree Nayak , Md Zillur Rahman","doi":"10.1016/j.jddst.2025.106896","DOIUrl":null,"url":null,"abstract":"<div><div>Cancer remains a major global health challenge, driving extensive research into developing advanced nano systems for precise and effective drug delivery. Carbon-based nanomaterials, particularly carbon nanotubes and quantum dots, have gained prominence due to their exceptional structural and physicochemical properties. These nanomaterials offer significant advantages, including high drug-loading capacity, enhanced biocompatibility, and reduced immunogenicity, making them highly promising candidates for cancer therapy. This review provides a detailed examination of the synthesis and functionalization of carbon nanostructures, highlighting recent advancements in their use for cancer drug delivery. Also, it analyzes their potential to improve therapeutic outcomes through targeted delivery mechanisms while addressing the challenges associated with their clinical translation. Furthermore, the review explores the prospects, challenges, and future directions of carbon nanotubes and quantum dots, focusing on their integration into clinical applications for cancer treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106896"},"PeriodicalIF":4.5000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Delivery Science and Technology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1773224725002990","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer remains a major global health challenge, driving extensive research into developing advanced nano systems for precise and effective drug delivery. Carbon-based nanomaterials, particularly carbon nanotubes and quantum dots, have gained prominence due to their exceptional structural and physicochemical properties. These nanomaterials offer significant advantages, including high drug-loading capacity, enhanced biocompatibility, and reduced immunogenicity, making them highly promising candidates for cancer therapy. This review provides a detailed examination of the synthesis and functionalization of carbon nanostructures, highlighting recent advancements in their use for cancer drug delivery. Also, it analyzes their potential to improve therapeutic outcomes through targeted delivery mechanisms while addressing the challenges associated with their clinical translation. Furthermore, the review explores the prospects, challenges, and future directions of carbon nanotubes and quantum dots, focusing on their integration into clinical applications for cancer treatment.
期刊介绍:
The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.