Investigating the Effect of Reducing the Signs and Symptoms of Lid Wiper Epitheliopathy in Patients With Dry Eye Disease With Perfluorohexyloctane

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2025-01-01 DOI:10.1016/j.curtheres.2025.100786

Chris Lievens OD, MS, PhD, FNAP, FAAO , Andrew D. Pucker OD, PhD, FAAO , Quentin Franklin BS , Stephen M. Montaquila OD, FAAO , Brad Giedd OD, MS, FAAO , Gina Wesley OD, MS, FAAO , Morgan Bromley PhD , Zackarias Coker MS , John Meyers MS , Marta Vianya-Estopa PhD

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引用次数: 0

Abstract

Background

Perfluorohexyloctane (PFHO) acts to prevent the evaporation of the tear film. It has the potential to limit friction related issues between the eye lid margin and the ocular surface. Prior to the present work, this had not yet been evaluated.

Objective

To examine the potential of using perfluorohexyloctane for reducing the signs and symptoms of lid wiper epitheliopathy (LWE).

Methods

Data were collected at 4 visits spanning 2 months. Patients who had symptomatic dry eye and a LWE score of ≥1.0 on the Korb LWE scale were recruited. Participants were randomized to PFHO 4 times a day or no treatment. Lid wiper epitheliopathy was graded at each visit with the Korb and photographic LWE (PLWE) scales. Symptoms were assessed using the Standard Patient Evaluation of Eye Dryness questionnaire and visual analog scales (0–100).

Results

A total of 52 participants were enrolled (mean ± SD age, 49.7 ± 15.7 years; 79% female). Right eyes in the treatment group were significantly more likely to show an improvement of ≥0.5-units in PLWE scores at 2 months than the no treatment group (P = 0.04), but no left eye differences were noted. Korb and PLWE scores were significantly better in the treatment group compared with the no treatment group starting at 2 weeks and remained so for the duration of the study (all P < 0.001). Standard Patient Evaluation of Eye Dryness scores and dry eye symptoms were significantly better in the treatment than in the no treatment group at the 2-month visit (all P ≤ 0.01).

Conclusions

Perfluorohexyloctane significantly reduced LWE and improved dry eye symptoms compared with no treatment, suggesting that PFHO may enhance ocular lubrication and reduce friction-related damage. Masked, randomized, trials are still needed to compare PFHO to other treatments in participants with LWE to support generalizability of results. ClinicalTrials.gov study NCT06671041.

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研究全氟己基辛烷减轻干眼症患者眼睑拭泪器表皮病变症状的效果

背景全氟己基辛烷（PFHO）具有防止泪膜蒸发的作用。它有可能限制眼睑边缘和眼球表面之间的摩擦问题。在本研究之前，还没有人对此进行过评估。目的研究使用全氟己基辛烷减轻睑板腺上皮炎（LWE）症状的潜力。招募的患者均为有症状的干眼症患者，且在 Korb LWE 量表中 LWE 评分≥1.0。参与者被随机分配到每天 4 次的 PFHO 或无治疗。每次就诊时，均使用 Korb 和摄影 LWE（PLWE）量表对睑板腺上皮病变进行评分。使用标准眼干患者评估问卷和视觉模拟量表（0-100）对症状进行评估。结果共有 52 名参与者（平均年龄为 49.7±15.7 岁；79% 为女性）参加了研究。2个月后，治疗组右眼的PLWE评分改善≥0.5个单位的几率明显高于未治疗组（P = 0.04），但左眼无差异。从 2 周开始，治疗组的 Korb 和 PLWE 评分明显优于未治疗组，并且在整个研究期间保持不变（所有 P 均为 0.001）。结论与不治疗相比，全氟己基辛烷能显著降低LWE并改善干眼症状，这表明全氟己基辛烷可能会增强眼部润滑并减少与摩擦相关的损伤。目前仍需进行掩蔽、随机试验，将PFHO与其他治疗方法在干眼症患者中进行比较，以证明试验结果的普遍性。ClinicalTrials.gov研究NCT06671041。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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