Solid-phase microextraction coupled to gas chromatography–Mass spectrometry as an advanced method for the determination of bioplasticizers in environmental and bottled water samples

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of Chromatography A Pub Date : 2025-04-04 DOI:10.1016/j.chroma.2025.465943

Nicolette Viktoryová , Agneša Szarka , Raquel Capilla-Flores , Francisco Javier Arrebola Liébanas

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引用次数: 0

Abstract

The aim of this work was the development of a novel analytical method for the extraction, separation, and determination of 21 bioplasticizers in water using direct immersion – solid phase microextraction in combination with gas chromatography-tandem mass spectrometry (DI-SPME-GC–MS/MS) to monitor these substances in the environment at low concentration levels. Incubation, extraction, and desorption parameters of the SPME procedure were optimised. All solutions were incubated in a heating chamber for 10 min at 70 °C, followed by SPME extraction for 60 minutes using 50/30 µm DVB/CAR/PDMS fiber. Thermal desorption followed at 270 °C for 3 min. Bioplasticizers were determined by GC–MS/MS. The method was validated, with LODs in range of 0.3 – 3 ng/mL, and LOQs 1 – 10 ng/mL for investigated bioplasticizers. The new method was applied for the analysis of real water samples. Positive results were found in real samples of agricultural water and bottled water in concentrations over 1 ng/mL. Five of the identified bioplasticizers were determined at concentrations in the range 1.43 – 3.44 ng/mL.

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固相微萃取-气相色谱-质谱联用法作为测定环境和瓶装水样品中生物增塑剂的先进方法

这项工作的目的是开发一种新型分析方法，利用直接浸没-固相微萃取结合气相色谱-串联质谱法（DI-SPME-GC-MS/MS）对水中的 21 种生物增塑剂进行萃取、分离和测定，以监测这些物质在环境中的低浓度水平。对 SPME 程序的孵育、萃取和解吸参数进行了优化。所有溶液均在 70 °C 的加热箱中孵育 10 分钟，然后使用 50/30 µm DVB/CAR/PDMS 纤维进行 60 分钟的 SPME 萃取。然后在 270 °C 下热解吸附 3 分钟。生物增塑剂通过 GC-MS/MS 进行测定。经验证，该方法对所研究的生物增塑剂的检出限为 0.3 - 3 ng/mL，定量限为 1 - 10 ng/mL。新方法被用于分析真实水样。在浓度超过 1 纳克/毫升的农业用水和瓶装水真实样本中发现了阳性结果。在已确定的生物增塑剂中，有五种生物增塑剂的浓度范围为 1.43 - 3.44 纳克/毫升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chromatography A 化学-分析化学

CiteScore

7.90

自引率

14.60%

发文量

742

审稿时长

45 days

期刊介绍： The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.