Acute effects of high-intensity interval exercise plus whole-body vibration on bone turnover markers, BDNF, irisin, and neurocognitive performance in postmenopausal women

Abstract

The acute effects of exercise can elucidate the molecular and psychophysiological mechanisms underlying exercise’s benefits in several systems (e.g., the brain, muscle, and bone). In this study, a single 30-minute session of high-intensity interval aerobic exercise (HIIAE) administered in conjunction with isometric resistance exercise on a whole-body vibration (WBV) platform (HIIAE+WBV) was compared with HIIAE alone in their effects on molecular and neurocognitive indices among 63 sedentary, healthy postmenopausal women who were randomly assigned to HIIAE (n = 20), HIIAE+WBV (n = 20), and Control (n = 23) groups. The assessed molecular indices were serum levels of osteocalcin (OC), uncarboxylated OC (ucOC), carboxylated OC (cOC), brain-derived neurotrophic factor (BDNF), and irisin, and the assessed neurocognitive indices were the accuracy rate (AR), reaction time (RT), and electroencephalography event-related potentials (ERPs) of P2 and P3 components in a visuospatial working memory task. Data on these indices before versus after an acute bout of HIIAE or HIIAE+WBV or after a resting session were compared. An HIIAE or HIIAE+WBV intervention yielded no significant change in ERP P2 latency/amplitude and P3 latency but yielded significantly higher ARs, shorter RTs, larger ERP P3 amplitudes, and higher OC, cOC, BDNF, and irisin levels in the postmenopausal women. HIIAE+WBV outperformed HIIAE alone in AR, ucOC, and BDNF. However, the changes in these molecular and neurocognitive indices induced by the two exercise modes did not show any significant correlations in the present study. The present findings suggest that HIIAE and HIIAE+WBV have the potential to acutely influence markers of bone and brain health, with HIIAE+WBV showing greater effectiveness than HIIAE alone. These interventions should be further investigated in future randomized controlled trials involving postmenopausal women.