Bioactive ceramic-coated carbon black particles/Polycaprolactone membranes for guided bone regeneration: Preparation, characterization and in vitro performance

IF 5.1 2区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Ceramics International Pub Date : 2025-04-01 DOI:10.1016/j.ceramint.2025.01.018

Hnin Nandar Soe , Matthana Khangkhamano , Jirut Meesane , Rungrote Kokoo , Sittichat Chukaew , Si Thu Myint Maung

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引用次数: 0

Abstract

Barrier membranes are normally employed in guided bone regeneration (GBR) procedures to facilitate bone tissue regeneration at the defect site. Despite being a suitable material for this purpose, polycaprolactone (PCL) is limited in clinical use due to its low degradation rate, inadequate wettability and bioactivity, and poor mechanical properties. This study explored TiC/TiO₂/SrCO₃-coated carbon black particles (TSrCB), a newly introduced bioactive nanocomposite agent, incorporated into PCL matrices as alternative barrier membranes for GBR. The research investigated the impact of TSrCB on the structural, physical, mechanical, thermal, and biological properties of PCL matrices. TSrCB particles were synthesized via molten salt synthesis and hydrothermal process before being incorporated into PCL for membrane fabrication using a solvent casting technique. Varying particle contents were tested. Results showed that adding TSrCB particles into PCL improved mechanical properties, degradation rate, and biological performance, including cell proliferation, adhesion, and protein synthesis in the nanoparticles membranes. Significant enhancement in physical, mechanical, and biological functions was noticed with higher TSrCB contents. The membrane with 20 % particle content was identified as a promising candidate for GBR.

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查看原文本刊更多论文

生物活性陶瓷包覆碳黑颗粒/聚己内酯膜引导骨再生：制备、表征和体外性能

在引导骨再生（GBR）过程中，屏障膜通常用于促进缺损部位的骨组织再生。尽管聚己内酯（PCL）是一种适合用于此目的的材料，但由于其低降解率、不充分的润湿性和生物活性以及较差的机械性能，在临床应用中受到限制。本研究探索了TiC/TiO2/ srco3包覆碳黑颗粒（TSrCB），一种新引入的生物活性纳米复合材料，作为GBR的替代屏障膜加入PCL基质中。研究了TSrCB对PCL基质的结构、物理、机械、热学和生物学性能的影响。采用熔盐法和水热法合成了TSrCB颗粒，然后采用溶剂铸造技术将TSrCB颗粒掺入PCL中制备膜。测试了不同的颗粒含量。结果表明，在PCL中加入TSrCB颗粒可以改善PCL的力学性能、降解速率和生物性能，包括细胞增殖、粘附和纳米颗粒膜中的蛋白质合成。TSrCB含量的增加显著增强了玉米的物理、机械和生物功能。颗粒含量为20%的膜被认为是很有前途的GBR候选膜。

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来源期刊

Ceramics International 工程技术-材料科学：硅酸盐

CiteScore

9.40

自引率

15.40%

发文量

4558

审稿时长

25 days

期刊介绍： Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.