The mechanical and biological performance of zinc-containing micro-arc oxidation film on titanium implant

IF 5.1 2区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Ceramics International Pub Date : 2025-04-01 DOI:10.1016/j.ceramint.2025.01.155

Jianghui Zhao , Lei Liu , Fengcang Ma , Ping Liu , Shengcai Qi , Wei Li , Ke Zhang , Xiaohong Chen

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Abstract

Titanium is extensively utilized in orthopedic and dental implants within contemporary medicine; however, shortcomings in its ability to resist bacterial infection and promote osseointegration often result in surgical failures. To address these shortcomings, this study prepared ceramic oxide films with varying zinc concentrations on TA4 substrates through one-step microarc oxidation. The microstructure, elemental composition, chemical characteristics, and corrosion resistance of the coatings were thoroughly investigated. The antimicrobial activity and biocompatibility of the films were assessed using antimicrobial tests and hydroxyapatite induction tests. The results indicate that the films exhibit a distinctive "volcano-like" porous morphology, primarily composed of anatase, rutile, and titanium phases. Notably, the incorporation of zinc into the electrolyte did not significantly alter the microstructure or physicochemical performance of the films. In vitro antimicrobial tests demonstrated that the incorporation of zinc significantly improved the antimicrobial performance of the films. Specifically, the antimicrobial activity of Ti-0.05Zn, Ti-0.1Zn, and Ti-0.25Zn against Staphylococcus aureus was measured at 25.5 %, 60.3 %, and 75.5 %, respectively. Additionally, the antimicrobial activity of the films against Porphyromonas gingivalis was recorded at 18.3 %, 51.7 %, and 92.8 %, respectively. Furthermore, the antimicrobial performance of the zinc-containing films remained relatively stable after 7 days of immersion in simulated body fluids, with hydroxyapatite particles forming on the surface, indicating that the films possess a degree of long-term antimicrobial capacity and exhibit favorable biocompatibility.

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含锌微弧氧化膜在钛种植体上的力学和生物学性能

钛在当代医学中广泛用于骨科和牙科植入物；然而，其抗细菌感染和促进骨整合能力的不足常常导致手术失败。为了解决这些缺点，本研究通过一步微弧氧化在TA4衬底上制备了不同锌浓度的陶瓷氧化膜。研究了涂层的显微组织、元素组成、化学特性和耐蚀性。采用抗菌试验和羟基磷灰石诱导试验对膜的抗菌活性和生物相容性进行了评价。结果表明，薄膜呈现出独特的“火山状”多孔形态，主要由锐钛矿、金红石和钛相组成。值得注意的是，在电解质中加入锌并没有显著改变薄膜的微观结构或物理化学性能。体外抗菌试验表明，锌的掺入显著提高了膜的抗菌性能。其中，Ti-0.05Zn、Ti-0.1Zn和Ti-0.25Zn对金黄色葡萄球菌的抑菌活性分别为25.5%、60.3%和75.5%。对牙龈卟啉单胞菌的抑菌活性分别为18.3%、51.7%和92.8%。此外，在模拟体液中浸泡7天后，含锌膜的抗菌性能保持相对稳定，表面形成羟基磷灰石颗粒，表明该膜具有一定的长期抗菌能力，并具有良好的生物相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ceramics International 工程技术-材料科学：硅酸盐

CiteScore

9.40

自引率

15.40%

发文量

4558

审稿时长

25 days

期刊介绍： Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.