Experimental Investigations into 4D Printing of Biocompatible Triple-Shape Memory Polymer Structures

IF 4.4 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2025-03-27 DOI:10.1021/acsapm.5c0048910.1021/acsapm.5c00489

Shubham Shankar Mohol, Doyel Ghosal, Pulak Mohan Pandey* and Sachin Kumar,

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Abstract

In this work, a triple-shape memory polymer was developed by solution blending of poly(lactic acid) (PLA) with poly(propylene carbonate) (PPC), which was 3D printed using the material extrusion principle. The blend of crystalline PLA and amorphous PPC enabled it to attain tunable mechanical properties. Morphological observations of blended PLA/PPC samples revealed a phase-segregated morphology, resulting in the appearance of two distinct glass transition temperatures, exhibiting a triple-shape memory effect (triple-SME). The PLA50/PPC50 composition achieved an optimum shape-fixity ratio (95.63%) and shape-recovery ratio (96.26%) due to the existence of a cocontinuous phase morphology. As a proof of concept, 4D printing of the PLA50/PPC50 composition was demonstrated at body temperature as a potential biomedical application to facilitate minimally invasive surgery. The in vitro degradation study of the PLA50/PPC50 composition resulted in a 7.5% mass loss over a period of 56 days. Finally, the in vitro cytotoxicity of all 3D printed PLA/PPC blends demonstrated excellent biocompatibility, proving their potential as an implant for tissue engineering applications. The elucidation of the parameters influencing the selective actuation of triple-SME gained from this study is expected to open a wide range of possibilities for use in biomedical devices.

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生物相容性三形状记忆聚合物结构的4D打印实验研究

在这项工作中，通过聚乳酸（PLA）和聚碳酸丙烯酯（PPC）的溶液共混，开发了一种三形状的记忆聚合物，并利用材料挤出原理进行了3D打印。结晶PLA和非晶PPC的共混使其具有可调的机械性能。对PLA/PPC共混样品的形貌观察表明，PLA/PPC共混样品具有相分离的形态，导致出现两种不同的玻璃化转变温度，表现出三形状记忆效应（triple-SME）。由于存在共连续相，PLA50/PPC50复合材料的固形比为95.63%，固形回收率为96.26%。作为概念验证，在体温下4D打印PLA50/PPC50组合物作为一种潜在的生物医学应用，以促进微创手术。在体外降解研究中，PLA50/PPC50组合物在56天内的质量损失为7.5%。最后，所有3D打印PLA/PPC混合物的体外细胞毒性都表现出出色的生物相容性，证明了它们作为组织工程植入物的潜力。从这项研究中获得的影响三重sme选择性驱动的参数的阐明有望为生物医学设备的使用开辟广泛的可能性。

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来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.