Diagnostic Accuracy of an Add-On, Blood-Based Screening Test for Colorectal Cancer in Two Established Screening Programmes

IF 6.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-04-10 DOI:10.1111/apt.70141

Tim L. Kortlever, Enea Ferlizza, Mattia Lauriola, Francesco Borrelli, Alberto Porro, Manon C. W. Spaander, Patrick M. Bossuyt, Luigi Ricciardiello, Evelien Dekker

引用次数: 0

Abstract

CELTiC is a blood-based test consisting of a panel of four mRNAs (CEACAM6, LGALS4, TSPAN8 and COL1A2) associated with colorectal cancer (CRC). CELTiC has a high sensitivity (90%) for detecting advanced neoplasia (AN) when compared to faecal immunochemical test (FIT)-negative subjects.

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在两个已建立的筛查方案中，一种附加的、基于血液的结直肠癌筛查试验的诊断准确性

CELTiC是一种基于血液的检测，包括与结直肠癌（CRC）相关的四种mrna （CEACAM6、LGALS4、TSPAN8和COL1A2）。与粪便免疫化学试验（FIT）阴性受试者相比，CELTiC在检测晚期肿瘤（AN）方面具有很高的灵敏度（90%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.