Solanum pan-genome highlights paralog diversification

IF 31.7 1区 生物学 Q1 GENETICS & HEREDITY
Wei Li
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引用次数: 0
龙葵泛基因组突出平行多样化
茄属是一个多样化的属,包括番茄(茄属)、马铃薯(茄属)、茄子(茄属)和非洲茄子(埃塞俄比亚茄属)等作物,非洲茄子是撒哈拉以南非洲的一种土著作物。Benoit等人从22个物种的染色体尺度基因组组装构建了茄属的泛基因组,捕获了丰富的表型和基因组多样性,并研究了平行进化动力学。在22个物种中发现了广泛的基因复制和平行分化。作者建立了两类平行对,即剂量限制或无剂量限制的正类群,并从不同的组织中生成了泛茄基因表达数据集。为了研究平行多样化对基因型-表型关系的影响,他们整合了跨物种的泛遗传学,发现了果实大小调节因子CLV3中修改的补偿关系。非洲茄子的泛基因组表明果实大小变异和CLV3平行分化。祖先冗余的CLE9平行序列的丢失由串联重复弥补,串联重复由于随后重复的CLV3基因的假原化而再次丢失,产生单个融合的CLV3等位基因。总的来说,该研究为茄属植物的平行进化提供了有价值的见解,并为未来的本土作物改良提供了机会。原始参考文献:Nature https://doi.org/10.1038/s41586-025-08619-6 (2025)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature genetics
Nature genetics 生物-遗传学
CiteScore
43.00
自引率
2.60%
发文量
241
审稿时长
3 months
期刊介绍: Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution
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