In danger: HIV vaccine research and development in Europe.

PLOS global public health Pub Date : 2025-04-08 eCollection Date: 2025-01-01 DOI:10.1371/journal.pgph.0004364
Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B Karlsson Hedestam, Hester Kuipers, Sheena McCormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre
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Abstract

Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has shrinked. This viewpoint emphasises that supporting HIV vaccine research and development at the European level remains crucial: it is not only necessary to control the epidemic, but it promotes innovation, strengthens health security, epidemic preparedness, and health sovereignty while contributing to the economies of European nations.

处于危险之中:欧洲的艾滋病毒疫苗研究和开发。
基于抗逆转录病毒的高效艾滋病毒预防在结束全球艾滋病毒/艾滋病流行方面发挥着重要作用。然而,包括艾滋病毒检测在内的预防选择机会不平等,以及耐药性和在获得可持续艾滋病毒治疗方面存在的障碍,阻碍了对这一流行病的可持续控制。因此,艾滋病毒疫苗加上有效的预防和治疗,仍然是控制这一流行病的绝对必要条件。然而,最近四项主要疫苗功效研究的中止引起了人们对全球艾滋病毒疫苗研究和开发的未来的关注,特别是在疫苗研究和开发资金减少的欧洲区域。这一观点强调,在欧洲一级支持艾滋病毒疫苗的研究和开发仍然至关重要:这不仅是控制这一流行病所必需的,而且还促进创新,加强卫生安全、流行病防范和卫生主权,同时为欧洲国家的经济作出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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