Lipidomics and temporal-spatial distribution of organelle lipid.

Journal of biological methods Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI:10.14440/jbm.2025.0094

Wenjuan Qian, Huiru Tang, Hongyan Yao

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Abstract

Background: Lipids are crucial signaling molecules or cellular membrane components orchestrating biological processes. To gain insights into lipid functions and the communication between organelles, it is essential to understand the subcellular localization of individual lipids. Advancements in lipid quantification techniques, improvements in chemical and spatial resolution for detecting various lipid species, and enhancements in organelle isolation speed have allowed for profiling of the organelle lipidome, capturing its temporal-spatial distribution.

Objective: This review examined approaches used to develop organelle lipidome and aimed to gain insights into cellular lipid homeostasis from an organelle perspective. In addition, this review discussed the advancements in lipid-mediated inter-organelle communication within complex physiological and pathological processes.

Conclusion: With the advancement of lipidomic technologies, more detailed explorations of organelle structures and the specific lipid-mediating functions they perform are feasible.

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脂质组学与细胞器脂质的时空分布。

背景：脂质是调控生物过程的重要信号分子或细胞膜成分。为了深入了解脂质功能和细胞器之间的交流，有必要了解单个脂质的亚细胞定位。脂质定量技术的进步，检测各种脂质的化学和空间分辨率的提高，以及细胞器分离速度的提高，使我们能够对细胞器脂质组进行分析，捕捉其时空分布。目的：本文综述了细胞器脂质组的研究方法，旨在从细胞器的角度了解细胞脂质稳态。此外，本文还综述了脂质介导的细胞器间通讯在复杂生理和病理过程中的研究进展。结论：随着脂质组学技术的进步，对细胞器结构及其特定的脂质介导功能进行更详细的探索是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of biological methods

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