PATCHY ATROPHIC PERIVASCULAR LESIONS IN VITREORETINAL LYMPHOMAS: A CASES SERIES.

Abstract

Purpose: Vitreoretinal lymphoma (VRL) is a rare but aggressive intraocular malignancy, often presenting diagnostic challenges due to its masquerade syndrome characteristics. This study reports on two atypical cases of VRL, highlighting the presence of patchy atrophic perivascular retinal lesions, a feature not commonly emphasized in the literature.

Methods: Cases series.

Results: The first case involves an 83-year-old woman with primary VRL in her right eye, where progressive atrophic retinal lesions were noted despite systemic chemotherapy. The second case describes a 77-year-old woman with secondary VRL, previously in remission from cerebral lymphoma, who also developed perivascular atrophic lesions in her right eye. These lesions were observed to increase in both number and size over time, even in the absence of active vitreoretinal infiltration or systemic disease relapse.

Conclusion: These cases suggest that the patchy atrophic perivascular lesions may be indicative of VRL. The atrophic progression, despite local disease control, underscores the importance of recognizing such patterns as part of the broader spectrum of VRL manifestations. It contributes to the ongoing discussion of minimal residual disease in VRL management.