Clinical Efficacy of Enhanced Contact Endoscopy in Early Detection of Laryngeal Carcinoma: A Single Center Experience.

IF 2.5 4区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of Voice Pub Date : 2025-04-07 DOI:10.1016/j.jvoice.2025.03.021

A Svejdova, M Homolac, P Kantor, J Satankova, L Zeinerova, J Krtickova, J Laco, V Chrobok

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引用次数: 0

Abstract

Introduction: Enhanced contact endoscopy (ECE) is a non-invasive technique used for the assessment of superficial vascular changes of mucosal lesions in high magnification. The aim of our study was to evaluate the clinical efficacy of ECE in an intraoperative settlement.

Methods: Structured assessment of laryngeal mucosal lesions using enhanced endoscopy (narrow band imaging (NBI) and ECE) was performed in a prospective clinical trial. Lesions were classified according to the European Laryngological Society Classification into non-suspicious and suspicious. Evaluations of endoscopic methods (NBI and ECE) were correlated with histopathology, histopathology being the gold standard. Sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), area under curve, diagnostic odds ratio (DOR), Kappa, incremental yield, and Youden´s index for NBI and ECE were calculated.

Results: A total of 110 patients with 136 lesions were enrolled, 50 benign non-neoplastic lesions, eight squamous cell papillomas, 45 dysplasias, and 33 squamous cell invasive cancers. Compared to NBI, ECE demonstrated higher sensitivity (91.0% vs 83.1%) and accuracy (90.4% vs 86.8%). NBI achieved higher specificity (91.8% vs 89.7%). PPV and NPV for ECE were 92.2% and 88.1%, whereas for NBI 93.1% and 80.4%. ECE showed greater overall diagnostic performance, with a DOR of 88.3 vs 55.2 and Kappa index of 0.805 vs 0.736.

Conclusions: ECE enhances diagnostic sensitivity and accuracy and represents a valuable addition to laryngeal cancer diagnostics.

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增强接触内窥镜在喉癌早期检测中的临床疗效：单中心经验。

简介：增强接触内窥镜（Enhanced contact endoscopy， ECE）是一种在高倍镜下评估粘膜病变浅表血管变化的非侵入性技术。我们研究的目的是评估ECE在术中沉降中的临床疗效。方法：在一项前瞻性临床试验中，采用增强内窥镜（窄带成像（NBI）和ECE）对喉粘膜病变进行结构化评估。病变根据欧洲喉学会分类分为非可疑和可疑。内镜方法（NBI和ECE）的评价与组织病理学相关，组织病理学是金标准。计算NBI和ECE的敏感性、特异性、准确性、阳性预测值（PPV）、阴性预测值（NPV）、曲线下面积、诊断优势比（DOR）、Kappa、增量产率和Youden指数。结果：共纳入110例患者136个病变，其中良性非肿瘤性病变50例，鳞状细胞乳头状瘤8例，发育不良45例，鳞状细胞浸润性癌33例。与NBI相比，ECE表现出更高的灵敏度（91.0% vs 83.1%）和准确性（90.4% vs 86.8%）。NBI具有更高的特异性（91.8% vs 89.7%）。ECE的PPV和NPV分别为92.2%和88.1%，而NBI的PPV和NPV分别为93.1%和80.4%。ECE显示出更高的整体诊断性能，DOR为88.3 vs 55.2， Kappa指数为0.805 vs 0.736。结论：ECE提高了诊断的敏感性和准确性，是喉癌诊断的一个有价值的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Voice 医学-耳鼻喉科学

CiteScore

4.00

自引率

13.60%

发文量

395

审稿时长

59 days

期刊介绍： The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.