Psychometric properties and longitudinal measurement invariance of the treatment-induced neuropathy assessment scale in the Chinese cancer chemotherapy population.

IF 3.8 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-04-08 DOI:10.1038/s41598-025-96978-5

Yanfei Jin, Yang Li, Lina Xiong, Chulei Tang, Hongwen Ma

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引用次数: 0

Abstract

Treatment-induced peripheral neuropathy is one of the most complex toxicities to diagnose and manage in cancer patients. The severity and course of neuropathy across various cancer treatments are widely assessed using the Treatment-Induced Neuropathy Assessment Scale (TNAS). However, the psychometric properties and longitudinal measurement invariance of TNAS have not been evaluated in non-Western samples. The purpose of this study was to evaluate psychometric properties and longitudinal measurement invariance of the TNAS in Chinese cancer patients. A quantitative survey with a longitudinal design was used in this study. A total of 361 patients were included and data were collected at three-time points. Confirmatory factor analysis (CFA), convergent validity, longitudinal measurement invariance, criterion validity, and internal consistency reliability were evaluated. In this study, CFA supported the 2-factor structure of the original TNAS construct at three time points. The composite reliability (CR) and the average variance extracted (AVE) indicated that the TNAS had good convergent validity. Furthermore, TNAS exhibited strong measurement invariance over time with good reliability across different time points. The correlation between TNAS and EORTC QLQ-CIPN20 showed good criterion validity. Moreover, the TNAS and sub-scales had high internal consistency at three time points. Thus, TNAS is a reliable and valid instrument with adequate psychometric properties and temporal stability for measuring treatment-induced peripheral neuropathy and tracking changes in neuropathy symptoms.

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中国癌症化疗人群治疗性神经病变评估量表的心理测量特性和纵向测量不变性。

治疗性周围神经病变是癌症患者诊断和治疗中最复杂的毒性之一。使用治疗性神经病变评估量表（TNAS）广泛评估各种癌症治疗中神经病变的严重程度和病程。然而，在非西方样本中，尚未对TNAS的心理测量特性和纵向测量不变性进行评估。本研究的目的是评估中国癌症患者TNAS的心理测量特性和纵向测量的不变性。本研究采用纵向设计的定量调查方法。共纳入361例患者，并在三个时间点收集数据。验证性因子分析（CFA）、收敛效度、纵向测量不变性、标准效度和内部一致性信度进行评估。在本研究中，CFA在三个时间点支持原始TNAS结构的2因素结构。综合信度（CR）和平均方差提取（AVE）表明，tas具有较好的收敛效度。此外，tas在不同时间点上表现出较强的测量不变性，具有良好的可靠性。TNAS与EORTC QLQ-CIPN20的相关性显示出良好的效度。此外，在三个时间点上，tas和子量表具有较高的内部一致性。因此，TNAS是一种可靠有效的仪器，具有足够的心理测量特性和时间稳定性，用于测量治疗性周围神经病变和跟踪神经病变症状的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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