Posterior Hyaloid Adhesion as an Optical Coherence Tomography Biomarker of Active Toxoplasma Retinochoroiditis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-04-08 DOI:10.1080/09273948.2025.2486366

Kiran Chandra, Rajeev Reddy Pappuru, Shabtab Nasir, Sucheta Ireni, Soumyava Basu, SriniVas Sadda, Hasnat Ali, Mudit Tyagi

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Abstract

Purpose: To explore the utility of Posterior Hyaloid Adhesions (PHA) as an Optical Coherence Tomography (OCT) biomarker of toxoplasma retinochoroiditi.

Methods: A retrospective review of OCT scans of infective retinitis cases to evaluate the presence of PHA at the time of presentation.

Results: Ninety-seven eyes of active toxoplasma retinochoroiditis and 125 eyes of retinitis of other etiologies were included. OCT feature of PHA was present in 70 eyes (72%) in the toxoplasmosis group as compared to other retinitis where it was present in 32 eyes (26%). Univariate analysis revealed that PHA was significantly more prevalent in toxoplasma retinochoroiditis compared to other retinitis. Multivariate analysis, adjusted for age and sex, revealed an odds ratio of finding PHA was 5.22 in patients with toxoplasma retinochoroiditis as compared to other retinitis. (p < 0.001).

Conclusion: PHA to a retinitis lesion can serve as a diagnostic OCT biomarker for active toxoplasma retinochoroiditis.

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.