Risk factors, clinical characteristics, and outcomes of perinatal stroke in a Tertiary University Hospital.

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2025-04-01 DOI:10.17712/nsj.2025.2.20240089

Shaden S Alfayez, Muddathir H Hamad, Amal Y Kentab, Ahmad A Alanezi, Daniah M Kurdi, Hanady A Almuhideb, Fahad A Bashiri

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Abstract

Objectives: To investigate the risk factors, clinical characteristics, and neurodevelopmental outcomes associated with perinatal stroke, as well as to assess the risk of epilepsy, seizure control, and cognitive function in children with perinatal stroke.

Methods: Data from 32 patients diagnosed with perinatal stroke between October 2007 and October 2020 were retrospectively reviewed.

Results: Of 32 patients, 27 were born after normal pregnancies, and 20 (62.5%) had consanguineous parents. Family histories of stroke, haematological disease, and epilepsy were noted in 3.13%, 3.13%, and 21.88%, respectively. Initial symptoms included hemiparesis (56.25%), seizures (37.5%), respiratory distress (3.13%), and tiptoe walking (3.13%). Epilepsy was diagnosed in 22 patients, with 72.72% achieving seizure control. Among 12 patients who underwent IQ testing, 15.63% had borderline impairment, 9.37% average IQ, 3.13% below-average IQ, and 6.26% moderate-to-severe impairment.

Conclusion: Hemiparesis was the most frequent presenting symptom, followed by seizures. Many patients developed epilepsy, with most achieving satisfactory seizure control. IQ testing revealed varying degrees of cognitive impairment, highlighting the complex neurodevelopmental effects of perinatal stroke.

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某大学附属医院围产期卒中的危险因素、临床特征及预后。

目的：探讨围产期卒中相关的危险因素、临床特征和神经发育结局，并评估围产期卒中患儿癫痫、发作控制和认知功能的风险。方法：回顾性分析2007年10月至2020年10月诊断为围产期卒中的32例患者的资料。结果：32例患者中，正常妊娠出生27例，近亲父母20例（62.5%）。卒中家族史、血液病家族史和癫痫家族史分别占3.13%、3.13%和21.88%。首发症状包括偏瘫（56.25%）、癫痫发作（37.5%）、呼吸窘迫（3.13%）和踮脚走路（3.13%）。22例患者被诊断为癫痫，72.72%的患者癫痫发作得到控制。在12例接受智商测试的患者中，有15.63%的人存在边缘性障碍，9.37%的人智商一般，3.13%的人智商低于平均水平，6.26%的人有中重度障碍。结论：偏瘫是最常见的症状，其次为癫痫发作。许多患者发展为癫痫，大多数患者获得了令人满意的癫痫控制。智商测试揭示了不同程度的认知障碍，突出了围产期中风对神经发育的复杂影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.