Fluorescent Orthodontic Adhesive With APTES-Modified ZnO Quantum Dots: Bond Strength, Cytocompatibility, and Clinical Feasibility.

IF 2.4 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Orthodontics & Craniofacial Research Pub Date : 2025-04-09 DOI:10.1111/ocr.12932

Jiarong Yan, Heng Sun, Zongshuai Liu, Zhonglu Yang, Ting Luo, Xiaozhu Liao, Nannan Wang, Hong He, Fang Hua

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引用次数: 0

Abstract

Introduction: To develop a fluorescent adhesive by incorporating 3-aminopropyltriethoxysilane (APTES)-modified ZnO quantum dots (A-ZnOQDs) and to evaluate its bond strength, rheological properties, cytocompatibility, and removal performance.

Methods: ZnOQDs were modified with APTES and blended with commercial orthodontic adhesive to construct the fluorescent adhesive, which was divided into four groups (0, 2, 4, and 6 wt.%). Shear bond strength (SBS) was measured with a universal testing machine. Rheological properties were evaluated through a dynamic shear rheometer (DSR) test. Cytocompatibility was assessed with a CCK-8 kit. Bracket bonding and debonding procedures were performed on a head simulator. Adhesive removal effectiveness during bonding and debonding procedures was assessed.

Results: There was no significant difference in SBS among four groups (0%: 10.06 ± 4.81 MPa, 2%: 8.98 ± 3.70 MPa, 4%: 10.88 ± 5.12 MPa, 6%: 8.09 ± 3.43 MPa, p > 0.05). DSR displayed that the rheological curves of group-2% and group-4% were close to that of group-0%. CCK-8 assay indicated cell vitality did not differ among group-0%, group-2%, and group-4% (p > 0.05). Group-4% showed less excess adhesive area (0%: 1.81 ± 1.58 mm², 4%: 0.95 ± 1.33 mm², p = 0.0465), less remnant adhesive area (0%: 0.73 ± 0.79 mm², 4%: 0.07 ± 0.21 mm², p = 0.0002), more time taken in removing excess adhesive (0%: 40.76 ± 6.44 s, 4%: 47.19 ± 8.40 s, p = 0.0046), and similar time taken in removing remnant adhesive (0%: 40.04 ± 10.05 s, 4%: 43.54 ± 10.18 s, p = 0.2365).

Conclusions: Fluorescent orthodontic adhesive containing 4 wt.% of A-ZnOQDs with reliable SBS, rheological properties, and cytocompatibility was successfully constructed, with proof that it can be recognised and removed efficiently.

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aptes修饰ZnO量子点荧光正畸胶粘剂：结合强度、细胞相容性和临床可行性。

前言：采用3-氨基丙基三乙氧基硅烷（APTES）修饰ZnO量子点（a - znoqds）制备荧光胶粘剂，并对其结合强度、流变性能、细胞相容性和去除性能进行了评价。方法：用APTES修饰ZnOQDs，与市售正畸胶粘剂混合制备荧光胶粘剂，分为4组（wt % 0、2、4、6）。剪切粘接强度（SBS）用万能试验机测定。通过动态剪切流变仪（DSR）试验评估了其流变特性。用CCK-8试剂盒评估细胞相容性。在头部模拟器上进行支架粘接和脱粘接操作。评估粘接和脱粘过程中的胶粘剂去除效果。结果：4组患者SBS发生率（0%:10.06±4.81 MPa, 2%: 8.98±3.70 MPa, 4%: 10.88±5.12 MPa, 6%: 8.09±3.43 MPa, p < 0.05）差异无统计学意义。DSR显示，2%组和4%组的流变曲线与0%组接近。CCK-8测定结果显示，0%组、2%组和4%组细胞活力差异无统计学意义（p < 0.05）。4%组的多余粘接面积较小（0%:1.81±1.58 mm2, 4%: 0.95±1.33 mm2, p = 0.0465），残留粘接面积较小（0%:0.73±0.79 mm2, 4%: 0.07±0.21 mm2, p = 0.0002），去除多余粘接所需时间较长（0%:40.76±6.44 s, 4%: 47.19±8.40 s, p = 0.0046），去除残留粘接所需时间相似（0%:40.04±10.05 s, 4%: 43.54±10.18 s, p = 0.2365）。结论：荧光正畸胶粘剂含4 wt。成功构建了具有可靠的SBS、流变学性质和细胞相容性的A-ZnOQDs，并证明其可以有效地识别和去除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orthodontics & Craniofacial Research 医学-牙科与口腔外科

CiteScore

5.30

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions. The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements. The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.