Effect of cinnamon oil (Cinnamomum burmannii) on the histological kidney of male diabetic rats (Rattus norvegicus).

IF 0.9 Q3 VETERINARY SCIENCES

Open Veterinary Journal Pub Date : 2025-02-01 Epub Date: 2025-02-28 DOI:10.5455/OVJ.2025.v15.i2.41

Budiastuti Budiastuti, Naomi Lan Noviana Thesia, Hani Plumeriastuti, Mustofa Helmi Effendi, Emmanuel Nnabuike Ugbo, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Katty Hendriana Priscilia Riwu, Riza Zainuddin Ahmad, Sheila Marty Yanestria, Wasito Wasito, Bima Putra Pratama, Mo Awwanah, Agung Prasetyo

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引用次数: 0

Abstract

Background: Chronic systemic disease known as diabetes mellitus is defined by elevated blood glucose levels and problems with fat, carbohydrate, and protein metabolism. In Indonesia, the cinnamon species found include Cinnamomum burmannii, which also has hypoglycemic activity. The primary antioxidant chemicals found in C. burmannii bark extract are polyphenols, which include tannins and flavonoids.

Aim: The antidiabetic activity of cinnamon essential oil (C. burmannii) against streptozotocin (STZ) was examined in this study.

Methods: STZ (45 mg/kg BW) was administered intraperitoneally as a single dose. Twenty male rats were employed in this investigation. The rats were divided into five groups: treatment 1 (P1) was administered with STZ and provided with 100 mg/kg BW; treatment 2 (P2) was administered with STZ and provided with 200 mg/kg BW; and treatment 3 (P3) was administered with STZ and provided with 400 mg/kg BW. The negative control group (K-) was not treated with STZ and was treated with 1% Tween 80. For 14 days, the medication was administered daily.

Results: The essential oil of cinnamon may lessen glomerulosclerosis, tubular necrosis, tubular degeneration, and glomerular necrosis. The kidney P3 treatment (400 mg/kg BW) produced negligible effects.

Conclusion: It is possible to create cinnamon essential oil as an herbal antidiabetic medication by lowering the degree of kidney cell damage.

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肉桂油对雄性糖尿病大鼠（褐家鼠）肾组织的影响。

背景：被称为糖尿病的慢性全身性疾病被定义为血糖水平升高和脂肪、碳水化合物和蛋白质代谢问题。在印度尼西亚，发现的肉桂种类包括肉桂，它也有降糖活性。缅树皮提取物中发现的主要抗氧化化学物质是多酚，其中包括单宁和类黄酮。目的：研究肉桂精油对链脲佐菌素（STZ）的抑制作用。方法：STZ （45 mg/kg BW）单次腹腔注射。本研究选用雄性大鼠20只。将大鼠分为5组：处理1 （P1）给予STZ，并给予100 mg/kg BW；处理2 （P2）给予STZ，并给予200 mg/kg BW；处理3 （P3）给予STZ，并给予400mg /kg BW。阴性对照组（K-）不给予STZ治疗，给予1% Tween 80治疗。连续14天，每天给药。结果：肉桂精油可减轻肾小球硬化、肾小管坏死、肾小管变性及肾小球坏死。肾脏P3处理（400 mg/kg BW）的影响可以忽略不计。结论：肉桂精油有可能通过降低肾细胞损伤程度而作为一种草药抗糖尿病药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.