Antimicrobial p-terphenyl derivatives from the deep-sea cold seep-derived fungus Aspergillus candidus.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-04-09 DOI:10.1080/14786419.2025.2487153

Yi-Yi Liu, Jing-Ya Shi, Qi-Ran Liang, Guang-Ying Chen, Hai-Xin Chen, Zhuang Han, Xu-Hua Nong

引用次数: 0

Abstract

Four new p-terphenyl derivatives named phenylcandilides C-F, together with nine known analogues, were isolated from the deep-sea cold-seep-derived fungus Aspergillus candidus HNNU0546. Compounds 10 and 12 exhibited antibacterial activity against Staphylococcus aureus with MIC values of 21.6 and 23.6 µM, respectively. Compound 5 showed antifungal activity with an EC₅₀ value of 3.0 µM against phytopathogenic fungus Alternaria sp., while compound 6 exhibited inhibitory activity against Curvularia australiensis and Alternaria sp. with the same EC₅₀ values of 3.0 µM, respectively.

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深海冷液源真菌假丝曲霉的抗菌对terphenyl衍生物。

从深海冷源真菌假丝曲霉HNNU0546中分离出4个新的对苯衍生物，命名为phenylcandilides C-F，以及9个已知的类似物。化合物10和12对金黄色葡萄球菌具有抗菌活性，MIC值分别为21.6µM和23.6µM。化合物5对植物病原真菌Alternaria sp.的抑菌活性为3.0µM，化合物6对澳大利亚曲霉（Curvularia australiensis）和Alternaria sp.的抑菌活性均为3.0µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.