Targeting diabetes with flavonoids from Indonesian medicinal plants: a review on mechanisms and drug discovery.

Abstract

The rich biodiversity of Indonesia provides a wide variety of plants rich in flavonoids, which show promising potential as antidiabetic agents. Flavonoids are polyphenolic compounds recognized for their broad biological activities, such as antioxidant, anti-inflammatory, and antidiabetic effects. Traditional Indonesian medicinal plants such as Syzygium cumini, Moringa oleifera, and Curcuma longa are currently being studied for their flavonoid content and potential in diabetes treatment. Studies suggest that flavonoids can influence crucial pathways in diabetes management, including enhancing insulin sensitivity, boosting insulin production, and safeguarding pancreatic β cells against damage caused by oxidative stress. For example, quercetin and kaempferol, flavonoids in many Indonesian plants, have demonstrated potential for managing glucose metabolism and lowering high blood sugar levels. Additionally, these substances have been shown to inhibit enzymes such as α-glucosidase and α-amylase, which are involved in the breakdown of carbohydrates, thus aiding in the regulation of blood sugar levels after meals. The antioxidant qualities of flavonoids play a crucial role in fighting oxidative stress and are a significant contributor to the development of diabetes and related complications. Flavonoids help neutralize free radicals and enhance the body's antioxidant protection, reducing oxidative harm and promoting metabolic wellness. Additionally, their anti-inflammatory properties aid in reducing the chronic inflammation linked to insulin resistance and β-cell dysfunction. Formulation advancements, such as nanocarrier technology, have been explored to boost the effectiveness of flavonoid-based therapies. Due to its vast plant diversity, Indonesia offers a potential reservoir for new antidiabetic drugs, meriting additional research and development with the aim of this review providing new knowledge on the potential of flavonoids that can play a role in the treatment of diabetes.