Endoscopic ultrasound-guided fine-needle aspiration in diagnosing primary medistinal large B-cell lymphoma: a case report.

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.3389/fonc.2025.1404211

Jingyan Tang, Yuchen Guan, Jianfeng Zhang, Chengqi Guan

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Abstract

Background: Mediastinal tumors present diagnostic challenges due to their unique location. This case report presents a patient diagnosed with primary mediastinal large B-cell lymphoma (PMBCL) using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), demonstrating the utility of this minimally invasive technique in detecting and confirming PMBCL.

Case description: A 34-year-old previously healthy woman came to our hospital complaining of dysphagia for 3 months. The gastroscopy showed a huge submucosal bulge in the middle of the esophagus, and a contrast-enhanced computed tomography scan of the chest revealed a left main bronchus nodule measuring 15 mm, mediastinal lymph node enlargement, and fusion with necrosis. Subsequently, we obtained the tissue from the mediastinal mass through EUS-FNA and the tissue from the left main bronchus nodule through transbronchoscope biopsy. According to the pathologic findings, we made a clear diagnosis: primary mediastinal large B-cell lymphoma.

Conclusion: As a minimally invasive technique, EUS-FNA is highly safe, repeatable, and accurate for lymphoma diagnosis. Although there are some limitations, it can play an important role in diagnosing mediastinal tumors.

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超声内镜引导下细针穿刺诊断原发性内侧大b细胞淋巴瘤1例。

背景：纵隔肿瘤因其独特的位置而给诊断带来挑战。本病例报告通过内窥镜超声引导下细针穿刺术（EUS-FNA）确诊了一名原发性纵隔大 B 细胞淋巴瘤（PMBCL）患者，展示了这种微创技术在检测和确诊 PMBCL 方面的实用性：一名 34 岁的健康女性来我院就诊，主诉吞咽困难 3 个月。胃镜检查显示食管中部粘膜下巨大隆起，胸部对比增强计算机断层扫描显示左主支气管结节长达 15 毫米，纵隔淋巴结肿大，融合伴坏死。随后，我们通过 EUS-FNA 获取了纵隔肿块的组织，并通过经支气管镜活检获取了左主支气管结节的组织。根据病理结果，我们做出了明确诊断：原发性纵隔大 B 细胞淋巴瘤：结论：作为一种微创技术，EUS-FNA 对淋巴瘤的诊断具有高度的安全性、可重复性和准确性。结论：作为一种微创技术，EUS-FNA 对淋巴瘤的诊断具有高度的安全性、可重复性和准确性，虽然存在一些局限性，但它在纵隔肿瘤的诊断中可以发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.