Development and validation of nomograms to forecast overall survival and cancer-specific survival in Asian patients diagnosed with epithelial ovarian cancer.
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Abstract
Objective: Asian females with ovarian cancer have different clinicopathological characteristics compared with other races. However, an effective prognostic prediction tool is lacking. The goal of our study was to develop and evaluate nomograms for estimating overall survival and cancer-specific survival in Asian patients with ovarian cancer.
Methods: We extracted data from 2010 to 2018 in the Surveillance, Epidemiology, and End Results database, focusing on Asian/Pacific Islander females that had been diagnosed with epithelial ovarian cancer. To find prognostic factors, least absolute shrinkage and selection operator Cox regression and multivariate Cox regression analyses were used. Based on the outcomes, nomograms were then constructed. Numerous techniques, such as the C-index, calibration plots, decision curve analysis, and risk subgroup stratification, were used to assess the performance of the nomograms.
Results: Nomograms were created to evaluate overall survival and cancer-specific survival rates over three and five years. The C-indices for overall survival and cancer-specific survival in the training cohort were 0.768 and 0.778, respectively. The C-indices for overall survival and cancer-specific survival in the validation cohort were 0.804 and 0.812, respectively. The calibration plots showed that the nomogram forecasts and actual survival results agreed. Additionally, the decision curve analysis curves indicated that the nomogram outperformed the American Joint Commission on Cancer staging system in terms of predictive accuracy.
Conclusion: Nomograms and a risk classification system were created to forecast the overall survival and cancer-specific survival of Asian females with ovarian cancer. The nomograms and risk stratification system have the potential to provide valuable assistance in making future clinical decisions.
期刊介绍：
Evidence of surgical interventions go back to prehistoric times. Since then, the field of surgery has developed into a complex array of specialties and procedures, particularly with the advent of microsurgery, lasers and minimally invasive techniques. The advanced skills now required from surgeons has led to ever increasing specialization, though these still share important fundamental principles.
Frontiers in Surgery is the umbrella journal representing the publication interests of all surgical specialties. It is divided into several “Specialty Sections” listed below. All these sections have their own Specialty Chief Editor, Editorial Board and homepage, but all articles carry the citation Frontiers in Surgery.
Frontiers in Surgery calls upon medical professionals and scientists from all surgical specialties to publish their experimental and clinical studies in this journal. By assembling all surgical specialties, which nonetheless retain their independence, under the common umbrella of Frontiers in Surgery, a powerful publication venue is created. Since there is often overlap and common ground between the different surgical specialties, assembly of all surgical disciplines into a single journal will foster a collaborative dialogue amongst the surgical community. This means that publications, which are also of interest to other surgical specialties, will reach a wider audience and have greater impact.
The aim of this multidisciplinary journal is to create a discussion and knowledge platform of advances and research findings in surgical practice today to continuously improve clinical management of patients and foster innovation in this field.
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