Association of maternal thyroid peroxidase antibody exposure with children's emotional and behavioral problems.

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

European Thyroid Journal Pub Date : 2025-04-24 Print Date: 2025-04-01 DOI:10.1530/ETJ-24-0302

Penggui Wu, Mengting Yang, Yuzhu Teng, Jiajun Ouyang, Wenjin Cai, Juan Tong, Guopeng Gao, Xiaoyan Wu, Yan Han, Shuangqin Yan, Fangbiao Tao, Kun Huang

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引用次数: 0

Abstract

Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioral problems in children.

Design: The study was designed as a cohort study.

Participants: Based on the Ma'anshan birth cohort in China, 2,464 mother-infant pairs were included in this study.

Measurements: Repeated blood samples were collected from pregnant women, and TPOAb and FT4 were measured retrospectively by electrochemiluminescence immunoassay (ECLIA). The strengths and difficulties questionnaire was used to assess the emotional and behavioral problems of 4-year-old preschoolers.

Results: After adjusting for potential confounders, maternal TPOAb positivity during the third trimester of pregnancy was found to be associated with an elevated risk of conduct problems in girls, with an odds ratio (OR) of 2.190 (95% confidence interval (CI): 1.137-4.219). Conversely, maternal TPOAb positivity in the first trimester was linked to a decreased incidence of prosocial behavior in boys, with an OR of 0.451 (95% CI: 0.237-0.861).

Conclusions: Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool-aged children.

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母亲甲状腺过氧化物酶抗体暴露与儿童情绪和行为问题的关系。

目的：母亲甲状腺过氧化物酶抗体（TPOAb）阳性与多种妊娠并发症有关，并对后代有潜在的神经心理发育影响。我们研究的目的是探讨母亲TPOAb水平对儿童情绪和行为问题的影响。设计：队列研究对象：基于中国马鞍山出生队列，纳入2464对母婴。测量方法：反复采集孕妇血样，采用电化学发光免疫分析法（ECLIA）回顾性测定TPOAb和FT4。采用优势与困难问卷（SDQ）对4岁学龄前儿童的情绪和行为问题进行评估。结果：在调整了潜在的混杂因素后，发现妊娠晚期母亲TPOAb阳性与女孩行为问题的风险增加有关，OR为2.190 （95% CI: 1.137 - 4.219）。相反，孕早期母亲TPOAb阳性与男孩亲社会行为发生率降低有关，OR为0.451 （95% CI: 0.237 - 0.861）。结论：母亲妊娠期TPOAb阳性可能与学龄前儿童的情绪和行为问题有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Thyroid Journal Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.70

自引率

2.10%

发文量

156

期刊介绍： The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.