Association of maternal thyroid peroxidase antibody exposure with children's emotional and behavioral problems.

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

European Thyroid Journal Pub Date : 2025-04-01 DOI:10.1530/ETJ-24-0302

Penggui Wu, Mengting Yang, Yuzhu Teng, Jiajun Ouyang, Wenjin Cai, Juan Tong, Guopeng Gao, Xiaoyan Wu, Yan Han, Shuangqin Yan, Fangbiao Tao, Kun Huang

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引用次数: 0

Abstract

Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioural problems in children.

Design: Cohort study Participants: Based on the Maanshan Birth Cohort in China, 2464 mother-infant pairs were included in this study.

Measurements: Repeated blood samples were collected from pregnant women and TPOAb and FT4 were measured retrospectively by electrochemiluminescence immunoassay (ECLIA). The Strengths and Difficulties Questionnaire (SDQ) was used to assess the emotional and behavioural problems of 4-year-old preschoolers.

Results: After adjusting for potential confounders, maternal TPOAb positivity during the third trimester of pregnancy was found to be associated with an elevated risk of conduct problems in girls, with an OR of 2.190 (95% CI: 1.137 - 4.219). Conversely, maternal TPOAb positivity in the first trimester was linked to a decreased incidence of prosocial behavior in boys, with an OR of 0.451 (95% CI: 0.237 - 0.861).

Conclusions: Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool - aged children.

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来源期刊

European Thyroid Journal Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.70

自引率

2.10%

发文量

156

期刊介绍： The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.