The effectiveness and sustained effects of exercise therapy to improve executive function in children and adolescents with autism: a systematic review and meta-analysis.

Abstract

This study rigorously examines the efficacy and sustained impact of exercise therapy on enhancing executive function among children and adolescents diagnosed with autism spectrum disorder (ASD). Furthermore, it conducts a comprehensive analysis of five distinct subgroups, categorized by variations in school age, exercise cycles, exercise characteristics, dimensions of executive function, and the administration of medication. A systematic search was conducted across the PubMed, EmBase, Cochrane Library, Web of Science, and SPORTDiscus databases to identify randomized controlled trials published from the inception of the library until October 20, 2024, focusing on the effects of exercise therapy on the enhancement of executive function in children and adolescents with ASD. Sixteen studies were systematically evaluated and included in the meta-analysis, revealing that exercise therapy led to a significant improvement in executive function among children and adolescents with ASD (SMD = 0.41, 95% CI [0.30, 0.52], P = 0.00), along with some evidence of sustained improvement (SMD = 0.74, 95% CI [0.29, 1.20], P = 0.00). Subgroup analyses indicated that exercise did not significantly enhance executive functioning in preschool-aged patients with ASD, and working memory did not exhibit a significant improvement across various dimensions of executive functioning. Furthermore, no differences were observed in analyses of different exercise cycles, exercise characteristics, or the use of medication among subjects.

Conclusion: Exercise interventions improve executive function in children and adolescents with ASD, with sustained post-intervention effects. Limited impact on working memory and observed heterogeneity highlights the need for more precise intervention designs and rigorous research.

What is known: • Exercise therapy is widely considered a promising non-pharmacological intervention for improving cognitive functions in children and adolescents with autism spectrum disorder (ASD). • Prior studies suggest exercise benefits executive function in ASD, but evidence on sustained effects and subgroup differences remains limited.

What is new: • This meta-analysis confirms that exercise therapy significantly and sustainably improves executive function in children and adolescents with ASD, with greater benefits observed in school-aged participants. • For the first time, subgroup analyses reveal age-dependent effects and confirm that working memory shows limited responsiveness to exercise, regardless of medication use or exercise characteristics.