Distribution of Troy (Tnfrsf19) in the Gastric Gland During Postnatal Development: Effects of Early Weaning.

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Biology International Pub Date : 2025-04-09 DOI:10.1002/cbin.70021

Isadora Campos Rattes, Kethleen Mesquita da Silva, Patrícia Gama

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Abstract

This study investigates the distribution and role of the stem cell marker Troy (Tnfrsf19) in the gastric mucosa of rats during postnatal development and the effects of early weaning. Troy, previously identified as a reserve stem cell marker in adult gastric tissues, is examined across various developmental stages from birth to adulthood. We showed that Troy+ cells are scattered throughout the gastric gland in early postnatal stages, but they become concentrated in the basal portion of the gland as the rats mature. Additionally, early weaning affects Troy expression at its gene and protein levels, altering its distribution in the gastric mucosa. This suggests that early dietary changes may disrupt the organization and function of the secondary stem cell niche in the stomach, potentially impacting gastric gland homeostasis. We also used in silico analysis to compare the molecular functions of Troy+ zymogenic and parietal cells, finding distinct roles in proliferation and secretion. The results underscore the importance of Troy in gastric development and highlight the long-term impact of early weaning on gastric tissue organization and cell proliferation dynamics.

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本研究调查了干细胞标记物特洛伊（Tnfrsf19）在大鼠胃粘膜中的分布和作用，以及早期断奶的影响。Troy以前曾被确定为成人胃组织中的储备干细胞标记物，我们研究了Troy在大鼠从出生到成年各个发育阶段的分布情况。我们发现，Troy+细胞在出生后早期散布于整个胃腺，但随着大鼠的成熟，它们会集中在胃腺的基底部分。此外，早期断奶会影响 Troy 基因和蛋白质水平的表达，改变其在胃粘膜中的分布。这表明，早期饮食变化可能会破坏胃中次级干细胞龛的组织和功能，从而可能影响胃腺的稳态。我们还利用硅分析比较了Troy+滋养细胞和顶叶细胞的分子功能，发现它们在增殖和分泌方面发挥着不同的作用。这些结果强调了特洛伊在胃发育中的重要性，并突出了早期断奶对胃组织和细胞增殖动态的长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biology International 生物-细胞生物学

CiteScore

7.60

自引率

0.00%

发文量

208

审稿时长

1 months

期刊介绍： Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect. These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.