Gender correlation between sleep duration and risk of coronary heart disease: a systematic review and meta-analysis.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1452006

Cun Li, Shun-Xin Luo, Tian-Wei Liang, Dan Song, Jin-Xiao Fu

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引用次数: 0

Abstract

Objective: The influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic.

Methods: This analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase. A two-stage hierarchical regression model evaluates potential linear dose-response relationships. Data analysis utilizes random-effects restricted cubic spline models with four knots.

Results: Involving 17 studies and 906,908 participants, this meta-analysis identifies a pronounced U-shaped nonlinear relationship between sleep duration and CHD risk applicable to both genders (P < 0.01). Notably, shorter sleep durations are linked to higher CHD risks in women, whereas longer durations are more consequential for men. The optimal sleep duration for minimizing CHD risk is between 7.0-8.0 h daily for men and 7.5-8.5 h for women.

Conclusion: The influence of sleep duration on CHD risk differs significantly between genders.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/myprospero, identifier (CRD42023478235).

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睡眠时间与冠心病风险的性别相关性：一项系统综述和荟萃分析

目的：极端睡眠时间对男女冠心病（CHD）风险的影响仍然是一个有争议的话题。方法：本分析收集了探索不同睡眠时间与冠心病风险之间关系的观察性研究。趋势估计采用广义最小二乘，将特定类别的风险估计转换为每小时睡眠增加的相对风险（RR）。两阶段层次回归模型评估潜在的线性剂量-反应关系。数据分析利用随机效应限制三次样条模型与四个结点。结果：本荟萃分析涉及17项研究，906,908名参与者，发现睡眠时间与冠心病风险之间存在明显的u型非线性关系，适用于男女(P结论：睡眠时间对冠心病风险的影响在性别之间存在显著差异。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/myprospero，标识符（CRD42023478235）。

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.