A comparison of pulmonary function pre and post mild SARS-CoV-2 infection among healthy adults.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2025-04-08 DOI:10.1186/s12890-025-03613-0

Raz Roje Taib, Yuval Kozlov, Aya Ekshtein, Barak Gordon, Ori Wand, Oded Ben-Ari

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引用次数: 0

Abstract

Background: SARS-CoV-2 infection frequently involves the respiratory system and may impact on pulmonary function tests (PFT) of recovered individuals. Studies which compare post-COVID-19 PFT to pre-illness measurements are scarce. The primary objective of this study was to assess the effect of COVID-19 on PFT soon after infection.

Methods: In this prospective observational study, PFT were measured early following recovery from COVID-19 among healthy military aircrew. Spirometry values were compared to pre-COVID-19 measurements, and abnormality rates of lung volumes and diffusion capacity for carbon monoxide (DLCO) were assessed.

Results: The study included 252 aviators, 97.6% males, mean age 34.9-years, following recovery from SARS-CoV-2 infection. Participants manifested mild symptoms (79.4%) or were asymptomatic (20.6%). Post-COVID-19 spirometry results 10.79 ± 5.67 days following infection were compared to measurements performed 41.3 ± 28.59 months earlier. Pre- and post-COVID-19 results were comparable, with similar minimal abnormalities rates (2% and 4.4%, respectively). In addition, there were no restrictive abnormalities following infection, and just 7.7% of individuals had a marginally low DLCO of 70-80% of predicted.

Conclusion: Among vaccinated, healthy adults, mild COVID-19 had no significant impact on PFT early post-infection. The data suggest that systematic PFT testing might not be necessary for asymptomatic healthy individuals who recovered from mild COVID-19.

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背景：SARS-CoV-2 感染经常累及呼吸系统，可能会影响康复者的肺功能测试（PFT）。将 COVID-19 后的肺功能测试与病前测量结果进行比较的研究很少。本研究的主要目的是评估 COVID-19 对感染后不久的 PFT 的影响：在这项前瞻性观察研究中，对健康的空军机组人员在 COVID-19 恢复后的早期进行了肺活量测量。将肺活量测定值与 COVID-19 前的测量值进行比较，并评估肺容积和一氧化碳弥散能力（DLCO）的异常率：研究对象包括 252 名感染 SARS-CoV-2 后康复的飞行员，其中 97.6% 为男性，平均年龄 34.9 岁。参与者表现出轻微症状（79.4%）或无症状（20.6%）。感染后 10.79 ± 5.67 天的 COVID-19 肺活量测量结果与 41.3 ± 28.59 个月前的测量结果进行了比较。COVID-19前和COVID-19后的结果相当，最小异常率相似（分别为2%和4.4%）。此外，感染后没有出现限制性异常，仅有 7.7% 的人的 DLCO 略低于预测值的 70-80%：结论：在接种疫苗的健康成年人中，轻度 COVID-19 对感染后早期的肺活量没有明显影响。这些数据表明，对于从轻度 COVID-19 感染中恢复的无症状健康人来说，可能没有必要进行系统的 PFT 检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.