THE ACUTE IMPACT OF LOWER BODY POSITIVE PRESSURE TREADMILL WALKING IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS: A PILOT STUDY.

IF 2.2 4区医学 Q1 REHABILITATION

American Journal of Physical Medicine & Rehabilitation Pub Date : 2025-03-26 DOI:10.1097/PHM.0000000000002733

Prakash Jayabalan, Chad Hanaoka, Sanchita Sen, Sarah Libfraind, Avraham Eisenstein, Vikram Darbhe

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Abstract

Objective: Determine acute symptomatic, gait, and biological effects of lower extremity loading during lower body positive pressure (LBPP) treadmill walking in individuals with knee osteoarthritis (OA).

Methods: Participants with knee OA (n = 32) above the age of 50 performed two-45-minute walking sessions at least 1 week apart. Individuals walked at self-selected speed on the treadmill at 100% bodyweight (BW) or 50%BW. The primary outcome was change in serum cartilage oligomeric matrix protein (COMP), with other outcome measures including change in knee joint pain, exercise intensity, gait parameters, and the concentration of other serum biomarkers of joint disease.

Results: Across all timepoints, 50%BW walking, was associated with significant reductions in knee pain compared to 100%BW (p < 0.05 for all) with no significant difference in duration of moderate-intensity exercise. 50%BW was associated with significant decreases in cadence (p < 0.001) and increased stride length (p = 0.008). Biomarker analyses demonstrated 100%BW walking was associated with a significant increase in COMP at 45 minutes compared to baseline (p = 0.032), not observed with 50% BW.

Conclusion: 50%BW walking in knee OA using an LBPP treadmill acutely reduces joint pain, improves gait parameters, and does not increase markers of cartilage turnover. Future studies should investigate the longitudinal benefits of this rehabilitation approach.

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下肢正压跑步机行走对膝骨关节炎患者的急性影响：一项初步研究。

目的：确定膝关节骨性关节炎（OA）患者在下体正压（LBPP）跑步机上行走时下肢负荷的急性症状、步态和生物学效应。方法：年龄在50岁以上的膝关节OA患者（n = 32）进行两次45分钟的步行，间隔至少1周。每个人在100%体重（BW）或50%体重（BW）的跑步机上以自己选择的速度行走。主要结局指标是血清软骨寡聚基质蛋白（COMP）的变化，其他结局指标包括膝关节疼痛、运动强度、步态参数和其他关节疾病血清生物标志物浓度的变化。结果：在所有时间点上，与100%体重相比，50%体重的步行与膝关节疼痛的显著减轻相关（p < 0.05），中等强度运动的持续时间无显著差异。50%体重与步幅显著降低（p < 0.001）和步幅增加（p = 0.008）相关。生物标志物分析表明，与基线相比，100%体重的步行与45分钟时COMP的显著增加相关（p = 0.032），而50%体重的步行则没有观察到COMP的增加。结论：50%体重的膝关节OA患者使用LBPP跑步机行走可显著减轻关节疼痛，改善步态参数，且不增加软骨转换标志物。未来的研究应该调查这种康复方法的纵向效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Physical Medicine & Rehabilitation 医学-康复医学

CiteScore

4.60

自引率

6.70%

发文量

423

审稿时长

1 months

期刊介绍： American Journal of Physical Medicine & Rehabilitation focuses on the practice, research and educational aspects of physical medicine and rehabilitation. Monthly issues keep physiatrists up-to-date on the optimal functional restoration of patients with disabilities, physical treatment of neuromuscular impairments, the development of new rehabilitative technologies, and the use of electrodiagnostic studies. The Journal publishes cutting-edge basic and clinical research, clinical case reports and in-depth topical reviews of interest to rehabilitation professionals. Topics include prevention, diagnosis, treatment, and rehabilitation of musculoskeletal conditions, brain injury, spinal cord injury, cardiopulmonary disease, trauma, acute and chronic pain, amputation, prosthetics and orthotics, mobility, gait, and pediatrics as well as areas related to education and administration. Other important areas of interest include cancer rehabilitation, aging, and exercise. The Journal has recently published a series of articles on the topic of outcomes research. This well-established journal is the official scholarly publication of the Association of Academic Physiatrists (AAP).