Extracellular Vesicles in Aging and Age-Related Diseases. How Important Are They?

IF 3.2 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
David J Lundy, Chia-Te Liao
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引用次数: 0

Abstract

Extracellular vesicles (EVs), lipid bilayer-bound particles secreted by cells, have attracted significant research attention for their roles in aging-related disorders, including cardiovascular disease, metabolic dysfunction, cancer, and neurodegeneration. Research shows that EV cargo and function are influenced by factors including age, disease state, exercise, nutrition and sleep, and they may modulate various aging-associated processes such as stem cell renewal, nutrient sensing, cell senescence, mitochondrial function, and insulin resistance. This perspective highlights, for a general audience, a selection of studies of EVs in aging and age-related diseases, and their diverse roles in organ crosstalk. While current evidence indicates that EVs play multiple roles in aging, there are numerous challenges including methodological challenges and limitations, heterogeneous reports of EV cargo, limited reproducibility, and apparent context-dependent effects of EVs and their cargo. Together, this limits the interpretation of these studies. This is proposed that EVs may act as fine-tuners of cellular communication within the broader aging-associated secretome and the importance of standardizing methods are emphasized. Last, future directions for EV research are suggested.

衰老和年龄相关疾病中的细胞外囊泡。它们有多重要?
细胞外囊泡(EVs)是由细胞分泌的脂质双分子层结合颗粒,因其在心血管疾病、代谢功能障碍、癌症和神经变性等衰老相关疾病中的作用而引起了广泛的研究关注。研究表明,EV的载重和功能受年龄、疾病状态、运动、营养和睡眠等因素的影响,并可能调节各种与衰老相关的过程,如干细胞更新、营养感知、细胞衰老、线粒体功能和胰岛素抵抗。对于普通读者来说,这一观点强调了ev在衰老和年龄相关疾病中的一系列研究,以及它们在器官相声中的不同作用。虽然目前的证据表明电动汽车在衰老过程中发挥着多种作用,但仍存在许多挑战,包括方法上的挑战和局限性、电动汽车货物的异质性报告、有限的可重复性以及电动汽车及其货物的明显环境依赖效应。总之,这限制了对这些研究的解释。这表明,ev可能在更广泛的衰老相关分泌组中充当细胞通信的微调器,并强调了标准化方法的重要性。最后,提出了电动汽车未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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