Association between changes in physical functions and risk of stroke: a prospective cohort study.

IF 6 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Yulin Xie, Yiling Lou, Shen Huang, Qingqing Jiang, Xiaohan Wang, Linlin Wang, Hengchang Wang, Furong Wang, Shiyi Cao
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引用次数: 0

Abstract

Background: The association between changes in physical functions and stroke incidence remains uncertain.

Methods: A total of 7978 participants without stroke from the China Health and Retirement Longitudinal Study (CHARLS) were recruited in 2011-2012 and followed up until 2020. We assessed annual changes in physical functions from 2011 to 2015, including absolute grip strength, relative grip strength, walking speed, chair-rising time and standing balance. The Cox proportional hazards model was applied to assess the longitudinal associations between annual changes in physical functions and stroke. Restricted cubic spline analyses were used to explore the dose-response relationships.

Results: During 71 714 person-years of follow-up, 549 incident stroke cases were reported. For each 1-kg absolute grip strength increment, 0.1-unit relative grip strength increment, or 1-point standing balance test score increment, the hazard of stroke was reduced by 12% [hazard ratio (HR): 0.88; 95% confidence interval (CI): 0.84-0.93], 53% (HR: 0.47; 95% CI: 0.34-0.64), 55% (HR: 0.45; 95% CI: 0.30-0.67), respectively. We found a negative linear dose-response association of the annual change in absolute and relative grip strength with incident stroke, as well as a nonlinear association between the annual change in standing balance and incident stroke. However, neither the annual change in walking speed nor chair-rising time was related to the incident stroke.

Conclusions: A greater improvement in absolute grip strength, relative grip strength or standing balance was suggested to be associated with a lower risk of stroke amongst middle-aged and older people. These objectively measured physical function changes are imperative for high-risk population classification and stroke prevention.

身体功能改变与中风风险之间的关系:一项前瞻性队列研究。
背景:身体功能改变与脑卒中发病率之间的关系尚不确定。方法:从2011-2012年中国健康与退休纵向研究(CHARLS)中招募7978名无卒中的参与者,随访至2020年。我们评估了2011年至2015年身体功能的年度变化,包括绝对握力、相对握力、步行速度、椅子上升时间和站立平衡。Cox比例风险模型用于评估身体功能年度变化与脑卒中之间的纵向关联。限制三次样条分析用于探讨剂量-反应关系。结果:在71 714人年的随访中,报告了549例卒中事件。绝对握力每增加1 kg,相对握力每增加0.1个单位,站立平衡测试分数每增加1分,卒中的危险性降低12%[风险比(HR): 0.88;95%可信区间(CI): 0.84-0.93], 53% (HR: 0.47;95% ci: 0.34-0.64), 55% (hr: 0.45;95% CI: 0.30-0.67)。我们发现绝对握力和相对握力的年变化与事件冲程呈负线性关系,站立平衡的年变化与事件冲程呈非线性关系。然而,步行速度和起身时间的年度变化与中风事件无关。结论:在绝对握力、相对握力或站立平衡方面的更大改善被认为与中老年人中风风险降低有关。这些客观测量的身体功能变化对于高危人群分类和中风预防是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Age and ageing
Age and ageing 医学-老年医学
CiteScore
9.20
自引率
6.00%
发文量
796
审稿时长
4-8 weeks
期刊介绍: Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.
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