Satenik Mkrtchyan, Vishal B Purohit, Vaibhav D Prajapati, Ronak V Prajapati, Oleksandr Shalimov, Sehrish Sarfaraz, Khurshid Ayub, Viktor O Iaroshenko
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引用次数: 0
Abstract
A convenient route for the mechanochemical synthesis of fluorinated aromatic compounds, that is, fluoro, trifluoromethyl, and trifluoromethoxy arenes, has been developed via pyrylium tetrafluoroborate (Pyry-BF4)-mediated desulfonamidative cross-coupling of primary sulfonamides under the synergy of a piezoelectric material BaTiO3, and Ru-catalysis. This is the first-ever report on the selective transformation of sulfonamide (SO2NH2) functionality to CF3/OCF3/F group in a single step under mechanochemical ball-milling conditions. Considering the importance of primary sulfonamides as the valuable pharmacophores, the present desulfonamidative cross-coupling approach could have potential to get synthetic utility in pharmaceutical industries for the late-stage functionalization of sulfonamide drugs and related active pharmaceutical ingredients (APIs).
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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