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{"title":"Preparation of polyhydroxyalkanoate nanocomposites for biomedical applications","authors":"Jia Chen, Chunjie Gong","doi":"10.1002/pi.6742","DOIUrl":null,"url":null,"abstract":"<p>Polyhydroxyalkanoates (PHAs) have been recognized as potential replacements for fossil fuel-based, non-biodegradable plastics. PHAs exhibit properties that are analogous to those of synthetic plastics. The production of PHAs offers a multitude of advantages, primarily due to their biodegradability and biocompatibility. The most naturally occurring form of PHAs are the polyhydroxybutyrates (P(3HB)s). The major limitations of P(3HB)s are their brittle nature and inferior mechanical properties. Hence, these biopolymers have been observed to have limited biotechnological applications. In contrast to P(3HB)s, copolymers of PHAs have almost all the desirable properties, making them suitable for high-end applications such as those in the medical sector. Structural modifications in PHA molecules have expanded the scope of their applications, including in medical implants, wound healing and bone grafts. It is noteworthy that considerable progress has been made in the field of PHA nanocomposites, which are now being explored for their biotechnological applications in drug delivery, tissue engineering and biosensors. The prospects for PHA nanocomposites are also summarized. © 2025 Society of Chemical Industry.</p>","PeriodicalId":20404,"journal":{"name":"Polymer International","volume":"74 5","pages":"405-414"},"PeriodicalIF":3.6000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer International","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pi.6742","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
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Abstract
Polyhydroxyalkanoates (PHAs) have been recognized as potential replacements for fossil fuel-based, non-biodegradable plastics. PHAs exhibit properties that are analogous to those of synthetic plastics. The production of PHAs offers a multitude of advantages, primarily due to their biodegradability and biocompatibility. The most naturally occurring form of PHAs are the polyhydroxybutyrates (P(3HB)s). The major limitations of P(3HB)s are their brittle nature and inferior mechanical properties. Hence, these biopolymers have been observed to have limited biotechnological applications. In contrast to P(3HB)s, copolymers of PHAs have almost all the desirable properties, making them suitable for high-end applications such as those in the medical sector. Structural modifications in PHA molecules have expanded the scope of their applications, including in medical implants, wound healing and bone grafts. It is noteworthy that considerable progress has been made in the field of PHA nanocomposites, which are now being explored for their biotechnological applications in drug delivery, tissue engineering and biosensors. The prospects for PHA nanocomposites are also summarized. © 2025 Society of Chemical Industry.
生物医学用聚羟基烷酸酯纳米复合材料的制备
聚羟基烷酸酯(PHAs)已被认为是化石燃料基、不可生物降解塑料的潜在替代品。pha表现出与合成塑料类似的特性。pha的生产具有许多优点,主要是由于它们的生物可降解性和生物相容性。聚羟基丁酸酯(P(3HB)s)是最自然存在的形式。P(3HB)s的主要缺陷是其脆性和较差的力学性能。因此,观察到这些生物聚合物在生物技术方面的应用有限。与P(3HB)s相比,pha共聚物几乎具有所有理想的性能,使其适用于高端应用,如医疗领域。PHA分子的结构修饰扩大了其应用范围,包括医疗植入物、伤口愈合和骨移植。值得注意的是,PHA纳米复合材料的研究已经取得了长足的进展,其在药物递送、组织工程和生物传感器等方面的生物技术应用正在探索中。展望了PHA纳米复合材料的发展前景。©2025化学工业协会。
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