Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-04-10 DOI:10.1111/jvim.70054

Dimitra A. Karra, Jan S. Suchodolski, Shelley J. Newman, Evgenia Flouraki, Jonathan A. Lidbury, Joerg M. Steiner, Panagiotis G. Xenoulis

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Abstract

Background

Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis.

Hypothesis/Objectives

To evaluate the efficacy of a single enema fecal microbiota transplantation (FMT) in improving intestinal dysbiosis and clinical scores in cats with CE.

Animals

Twenty-eight cats with either chronic inflammatory enteropathy (CIE; n = 19) or small cell gastrointestinal lymphoma (SCGL; n = 9) were prospectively enrolled.

Methods

Eleven cats were randomly selected to receive a single enema FMT (FMT-group), and 17 cats were used as controls. Clinical activity was determined using the Feline Chronic Enteropathy Activity Index (FCEAI), and intestinal dysbiosis was determined using the feline dysbiosis index (DI) on the day of FMT (T0) and 30 days after FMT (T1).

Results

At T0, 14/28 cats had an abnormal DI > 0. No significant difference was found in the DI from T0 to T1 in the FMT group (mean[SD]: 0.01[2.5] vs. 0.7[2.1]; p = 0.47). No significant difference was found in the DI between the FMT group and the control group at T1 (mean[SD]: −0.7[2.1] vs. 0.8[1.8]; p = 0.92). FCEAI significantly decreased at T1 compared to T0 in the FMT group (median[IQR] 10.0[7.7–11.3] vs. 4.5[4–5]; p = 0.002). No significant difference was found in the FCEAI between the FMT group and the control group at T1 (median[IQR] 4.5[4–5] vs. 4[3–5.75]; p = 0.64).

Conclusions

In this study, single enema FMT did not lead to a significant improvement in DI or FCEAI in cats with CE compared to controls.

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慢性肠病猫单次灌肠粪便菌群移植

背景：慢性肠病（CE）在猫中很常见，肠道菌群的改变可能参与了其发病机制。假设/目的评估单次灌肠粪便微生物群移植（FMT）对改善CE猫肠道生态失调和临床评分的效果。28只猫患有慢性炎症性肠病(CIE；n = 19)或小细胞胃肠道淋巴瘤(SCGL；N = 9)被纳入前瞻性研究。方法随机选择11只猫接受单次FMT灌肠治疗（FMT组），17只猫作为对照组。采用猫慢性肠病活动指数（FCEAI）测定临床活动性，采用猫生态失调指数（DI）测定FMT当天（T0）和FMT后30天（T1）的肠道生态失调。结果28只猫中有14只出现DI异常；FMT组在T0与T1的DI无显著差异(mean[SD]: 0.01[2.5] vs. 0.7[2.1]；p = 0.47)。FMT组与对照组在T1时的DI无显著差异(mean[SD]:−0.7[2.1]vs. 0.8[1.8]；p = 0.92)。与T0相比，FMT组在T1时FCEAI显著降低(中位数[IQR] 10.0[7.7-11.3]对4.5[4-5]；p = 0.002)。FMT组与对照组在T1时FCEAI无显著差异(中位数[IQR] 4.5[4 - 5]比4[3-5.75]；p = 0.64)。在本研究中，与对照组相比，单次灌肠FMT并没有显著改善CE猫的DI或FCEAI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.