Insights into electrospun polymeric nanofiber mats: an innovative dressing for wound healing applications

IF 3.6 4区化学 Q2 POLYMER SCIENCE

Polymer International Pub Date : 2024-12-12 DOI:10.1002/pi.6736

Bimal Rajchal, Yub Narayan Thapa, Deepshikha Karki, Prabha Prajapati, Rameshwar Adhikari

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Abstract

Wound management is a complex clinical challenge that needs advanced materials and techniques for satisfactory results. Electrospun nanofiber mats have emerged as an innovative alternative for wound healing purposes due to their porous architecture, greater surface area, ease of water absorption, mimicry of the extracellular matrix of natural tissues and tunable mechanical properties. This paper sheds light on recent advances in the fabrication techniques, properties, structural features and application of electrospun polymeric nanofiber mats for wound healing purposes emphasizing the importance of polymer selection and processing parameters in tailoring their physicochemical properties. Furthermore, the review explores the underlying principles of the wound healing process and various approaches to incorporating bioactive agents into nanofiber mats to enhance their biological performance and wound healing potential. The possibility of embedding stimuli-responsive sensors into the nanofiber mats to develop smart mats is also briefly explored. © 2024 Society of Chemical Industry.

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洞察电纺聚合物纳米纤维垫：创面愈合应用的创新敷料

伤口管理是一项复杂的临床挑战，需要先进的材料和技术才能取得令人满意的结果。由于其多孔结构、更大的表面积、易于吸水、模仿自然组织的细胞外基质和可调的机械性能，电纺纳米纤维垫已成为伤口愈合目的的创新替代品。本文介绍了电纺高分子纳米纤维伤口愈合垫的制备技术、性能、结构特点和应用的最新进展，强调了聚合物选择和工艺参数对其理化性能的影响。此外，本文还探讨了伤口愈合过程的基本原理，以及在纳米纤维垫中加入生物活性物质以提高其生物性能和伤口愈合潜力的各种方法。本文还简要探讨了在纳米纤维垫子中嵌入刺激响应传感器以开发智能垫子的可能性。©2024化学工业学会。

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来源期刊

Polymer International 化学-高分子科学

CiteScore

7.10

自引率

3.10%

发文量

135

审稿时长

4.3 months

期刊介绍： Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.