Scaling nanopharmaceutical production for personalized medicine: challenges and strategies

IF 2.1 4区 材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Carolina de Souza Cardoso Delfino, Michelle Colão de Paula Pereira, Marcella dos Santos Oliveira, Isabela de Carvalho Favareto, Viviane Silva Valladão, Milena de Oliveira Mota, Maria Victória Barros Costa, Ariane Jesus Sousa-Batista, Tiago Albertini Balbino
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引用次数: 0

Abstract

Nanomedicine has emerged as a transformative field, offering enhanced drug delivery systems with reduced toxicity through the use of nanopharmaceuticals. Scaling up the production of these systems is critical for the successful translation of personalized nanomedicine into clinical practice. This review addresses the challenges and strategies involved in large-scale manufacturing, focusing on key methodologies such as nanocrystallization, extrusion, supercritical fluid technology, and microfluidics. A detailed comparative analysis of these production methods reveals their scalability, cost implications, and impact on nanoparticle characteristics, such as size and reproducibility. Additionally, we examine the complex regulatory landscape, highlighting regional differences in approval requirements from agencies. These regulatory variations pose significant challenges for global manufacturers seeking to scale up production while maintaining compliance with diverse standards. The review also explores the critical role of good manufacturing practices (GMP) and quality-by-design approaches in ensuring batch-to-batch consistency, offering a roadmap for overcoming the technical and regulatory hurdles essential for advancing nanomedicine to widespread clinical applications. Therefore, by addressing these barriers, nanopharmaceuticals hold the potential to revolutionize personalized medicine with more effective, targeted therapies for complex diseases.

为个性化医疗规模化生产纳米药物:挑战和策略
纳米医学已经成为一个变革性的领域,通过使用纳米药物提供增强的药物输送系统,降低毒性。扩大这些系统的生产规模对于个性化纳米医学成功转化为临床实践至关重要。本文综述了大规模制造的挑战和策略,重点介绍了纳米晶化、挤压、超临界流体技术和微流体等关键方法。对这些生产方法进行了详细的比较分析,揭示了它们的可扩展性、成本以及对纳米颗粒特性(如尺寸和可重复性)的影响。此外,我们还研究了复杂的监管环境,强调了各机构批准要求的地区差异。这些监管变化对寻求扩大生产规模同时保持不同标准合规性的全球制造商构成了重大挑战。这篇综述还探讨了良好生产规范(GMP)和设计质量方法在确保批次到批次一致性方面的关键作用,为克服技术和监管障碍提供了路线图,这些障碍对于推动纳米药物广泛临床应用至关重要。因此,通过解决这些障碍,纳米药物有可能通过更有效、更有针对性的治疗复杂疾病来彻底改变个性化医疗。
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来源期刊
Journal of Nanoparticle Research
Journal of Nanoparticle Research 工程技术-材料科学:综合
CiteScore
4.40
自引率
4.00%
发文量
198
审稿时长
3.9 months
期刊介绍: The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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