Nanotechnology-assisted lung cancer diagnosis: biomarkers and imaging

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-04-10 DOI:10.1007/s11051-025-06270-w

Sina Maskoukian, Ayda Moradi, Mahdi Shokri, Armina Shirangi, Tomasz Bączek, Navid Rabiee, Mohammad Reza Saeb, Mehdi Farokhi, Fatemeh Mottaghitalab

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引用次数: 0

Abstract

Lung cancer is one of the most deadly types of cancer, worldwide. It is essential to diagnose lung cancer in the early stage to accelerate the therapeutic process. The progress in nanotechnology-assisted therapies has revolutionized early diagnosis of lung cancer by developing non-invasive, selective, and highly sensitive nanostructures. Nanoparticles (NPs) have been widely used to improve the diagnosis and treatment of lung tumors due to their small size relative to human cells. The NPs can skip the barriers and target the proteins associated with tumor cells through either intracellular or extracellular action. Moreover, by using nanosensors, it is possible to detect specific biomarkers related to lung cancer in the early stages. This review is aimed at summarizing, classifying, and interpreting outcomes of reports on the application of NPs in detecting lung cancer. The survey revealed that NPs are used in three pathways to detect cancer, including detection of biomarkers, detection of cancer cells, and in vivo tumor imaging. Once the significance or limitation of each approach in the diagnosis of lung cancer is examined, their relative relevance is inferred.

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.