Preparation of Starch Biopolymer Decorated Bimetallic Metal-Organic Framework (Mn-Zn) Bio-nanocomposite for pH-Controlled Drug Delivery

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2025-03-01 DOI:10.1007/s10924-025-03545-0

Malihe Pooresmaeil, Rahim Safarpour, Hassan Namazi

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引用次数: 0

Abstract

For the first time, this research aims to prepare a new photoluminescence and porous bio-nanocomposite of the starch nanoparticles@metal-organic framework (Manganese-Zinc) (PSt NPs@MOF(Mn-Zn)) through the composition of starch nanoparticles (St NPs), carbon dots (CDs), and MOF(Mn-Zn) in three steps. The findings of performed characterization techniques approved the success in the fabrication of the PSt NPs@MOF(Mn-Zn). In the following, the potential of PSt NPs@MOF(Mn-Zn) was evaluated as a drug carrier for co-delivery of doxorubicin (DOX) and 5-fluorouracil (5-Fu) and ((5-Fu+DOX)@PSt NPs@MOF(Mn-Zn)) was obtained. Brunauer-Emmett-Teller (BET) test showed that the surface area and total pore volume of 275.98 m² g^-1 and 0.4885 cm³ g^-1 for PSt NPs@MOF(Mn-Zn) were reduced to 3.8535 m² g^-1 and 0.0029023 cm³ g^-1 for (5-Fu+DOX)@PSt NPs@MOF(Mn-Zn) that is a good indication of the loading of studied drug molecules in the prepared system. Moreover, the higher release rate of DOX and 5-Fu at pH 5.0 than pH 7.4 is one of the main signs of the system's suitability in cancer treatment. The observation of HeLa cell viability up to 70% after treatment with PSt NPs@MOF(Mn-Zn) approved its biocompatibility and its potential for use as a drug carrier. Overall it can be concluded that the PSt NPs@MOF(Mn-Zn) has the criteria to be proposed as a new bio-nanocomposite for controlled DOX and 5-Fu delivery.

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.