A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2025-04-01 DOI:10.1016/j.chmed.2025.01.003

Yuanyuan Zhang , Fazhi Su , Enlin Zhu , Yanping Sun , Haixue Kuang , Qiuhong Wang

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引用次数: 0

Abstract

Ferroptosis is a unique regulated form of cell death that is distinct from apoptosis, necrosis, and other well-characterized regulated cell death types, and plays an important role in the occurrence and development of chronic metabolic diseases, including diabetes, hypertension, hyperlipidemia, and non-alcoholic steatohepatitis. Recently, increasing evidence has supported traditional Chinese medicine (TCM) as a new hot spot for the treatment of chronic metabolic diseases by mediating ferroptosis. Unfortunately, few systematic reviews have described the importance of TCM in treating chronic metabolic diseases through the ferroptosis pathway. In the current review, the mechanism of ferroptosis and the roles of ferroptosis in chronic metabolic diseases are summarized. Additionally, this review illustrates that the regulation of ferroptosis by TCM could be an effective approach for treating chronic metabolic diseases based on experimental evidence and clinical application. In summary, this work will improve the understanding of ferroptosis and the ability of TCM to regulate ferroptosis in chronic metabolic diseases, thereby promoting the development and application of natural TCM.

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从实验证据和临床应用角度对中药调节铁下垂治疗慢性疾病进行系统综述

Ferroptosis是一种独特的受调控的细胞死亡形式，不同于凋亡、坏死和其他已知的受调控的细胞死亡类型，在慢性代谢性疾病（包括糖尿病、高血压、高脂血症和非酒精性脂肪性肝炎）的发生和发展中起重要作用。近年来，越来越多的证据支持中医药作为通过介导铁下垂治疗慢性代谢性疾病的新热点。不幸的是，很少有系统的综述描述中医药在通过铁下垂途径治疗慢性代谢性疾病中的重要性。本文就铁下垂的机制及其在慢性代谢性疾病中的作用作一综述。此外，本文从实验证据和临床应用的角度阐述了中医药对铁下垂的调控可能是治疗慢性代谢性疾病的有效途径。综上所述，本工作将提高对铁下垂的认识以及中医药对慢性代谢性疾病铁下垂的调控能力，从而促进天然中药的开发和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.