Prevention and treatment of radiation injury by traditional Chinese medicine: A review

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL
Lixue He , Shixing Edi , Jun Ma , Zilin Kong , Chunguang Dai , Linfang Huang , Rui Zeng , Kaijun Gou
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引用次数: 0

Abstract

Nuclear radiation exposure events and tumor radiotherapy are highly susceptible to a range of psychological, physiological and other health problems, which can seriously affect patients’ quality of life. It has been shown that 87.5 % of tumor patients are exposed to varying degrees of radiation injury during radiotherapy. The treatment of radiation injury (RI) in modern medicine is limited to drug therapy, cell therapy, etc. Among them, the most chemical drugs cause many adverse reactions including fatigue, nausea, vomiting, etc., and there are very few drugs dedicated to the treatment of RI. Traditional Chinese medicine (TCM) is a rich natural medicinal resource, which has a wide range of pharmacological activities, multiple targets of action and minimal toxic side effects. Many studies have demonstrated that TCM and its compound preparations have enormous potential in the treatment of radiation induced comprehensive diseases. However, TCM is limited in clinical application due to its slow onset of action, complex active ingredients, and low bioavailability. Therefore, the article reviews the application, molecular mechanisms, and new dosage forms of TCM in the prevention and treatment of RI. On this basis, we will focus on discussing the development advantages and application prospects of the combination of traditional Chinese and Western medicine to achieve highly efficient treatment of RI. This review aims to provide scientific and effective drug delivery strategies and basic theoretical support for the clinical effective treatment of RI with TCM, and further promote the innovative development of TCM.
中医药防治辐射损伤的研究进展
核辐射暴露事件和肿瘤放疗极易引起一系列心理、生理和其他健康问题,严重影响患者的生活质量。已有研究表明,87.5%的肿瘤患者在放疗过程中受到不同程度的辐射损伤。现代医学对放射性损伤的治疗仅限于药物治疗、细胞治疗等。其中,化学药物最多,会引起疲劳、恶心、呕吐等不良反应,专门用于治疗RI的药物很少。中药是一种丰富的天然药物资源,具有药理活性广泛、作用靶点多、毒副作用小等特点。许多研究表明,中药及其复方制剂在治疗辐射引起的综合性疾病方面具有巨大的潜力。但中药起效慢、有效成分复杂、生物利用度低,限制了其临床应用。因此,本文就中药在防治RI中的应用、分子机制、新剂型等方面进行综述。在此基础上,重点探讨中西医结合实现RI高效治疗的发展优势及应用前景。本文旨在为中药临床有效治疗RI提供科学有效的给药策略和基础理论支持,进一步促进中医药的创新发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
期刊介绍: Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.
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