Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-04-10 DOI:10.1016/j.bioactmat.2025.04.001

Yunan Lu , Ting Zhang , Kai Chen , Federico Canavese , Chenyang Huang , Hongtao Yang , Jiahui Shi , Wubing He , Yufeng Zheng , Shunyou Chen

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Abstract

Over the past two decades, advances in pediatric orthopedics and closed reduction combined with percutaneous internal fixation techniques have led to significant growth in pediatric orthopedics surgery. Implants such as Kirschner-wires, cannulated screws and elastic stabilization intramedullary nails are commonly used in these procedures. However, traditional implants made of metal or inert materials are not absorbable, leading to complications that affect treatment outcomes. To address this issue, absorbable materials with excellent mechanical properties, good biocompatibility, and controlled degradation rates have been developed and applied in clinical practice. These materials include absorbable polymers and biodegradable metals. This article provides a comprehensive summary of these resorbable materials from a clinician's perspective. In addition, an in-depth discussion of the feasibility of their clinical applications and related research in pediatric orthopedics is included. We found that the applications of absorbable implants in pediatric orthopedics are shifting from absorbable polymers to biodegradable metals and emphasize that the functional characteristics of resorbable materials must be coordinated and complementary to the treatment in pediatric orthopedics.

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生物可降解植入物在儿科骨科中的应用：从可吸收聚合物到生物可降解金属的转变

在过去的二十年里，儿科骨科和闭合复位结合经皮内固定技术的进步导致了儿科骨科手术的显著增长。植入物如克氏针、空心螺钉和弹性稳定髓内钉通常用于这些手术。然而，由金属或惰性材料制成的传统植入物是不可吸收的，导致影响治疗结果的并发症。为了解决这一问题，人们开发了具有优异机械性能、良好生物相容性和可控制降解率的可吸收材料，并将其应用于临床实践。这些材料包括可吸收的聚合物和可生物降解的金属。本文从临床医生的角度对这些可吸收材料进行了全面的总结。并对其在小儿骨科临床应用及相关研究的可行性进行了深入探讨。我们发现可吸收植入物在儿科骨科中的应用正在从可吸收聚合物转向生物可降解金属，并强调可吸收材料的功能特性必须与儿科骨科治疗相协调和互补。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.